著者

玉井 和樹 小林 馨 五十嵐 千浪 小佐野 貴識

出版者

特定非営利活動法人 日本歯科放射線学会

雑誌

歯科放射線 (ISSN:03899705)

巻号頁・発行日

vol.53, no.3, pp.21-27, 2013 (Released:2013-12-10)

参考文献数

23

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Objective: In recent years, it has been postulated that a change in muscle function is associated with the etiology of obstructive sleep apnea (OSA). Saito and colleagues previously reported the impact of obesity on the properties of the lingual muscles (genioglossus and geniohyoid) in rats (Arch Oral Biol (2010; 55(10): 803-808)). However, in previous images, fat to muscle metamorphosis was not shown in humans. Here, we provide evidence of fatty metamorphosis in the lingual muscles using computed tomography (CT) images of patients with suspected OSA.Materials and methods: The subjects were 62 patients (47 male, 15 female) with suspected OSA, who visited Tsurumi University School of Dental Medicine from November 2007 to October 2011. All subjects gave informed consent to take part in the study. The subjects underwent CT evaluations at the image diagnosis department of the hospital. Sex, age, body mass index (BMI), and apnea hypopnea index (AHI) were recorded for each patient. Inferior airway space and the total value of length and width of the inferior airway space (TIAS) were also measured. The degree of fat to muscle metamorphosis was measured using CT. Aze Win image analysis software was used to set a region of interest (ROI) of 30mm2 on the belly muscle of the lingual muscles. We measured CT levels of four ROIs (both sides of the central area and both sides of the posterior area) in the genioglossus muscles and two sizes of ROI (both sides of the central area) in geniohyoid muscles. Values were quantified and compared statistically.Results: The median values (25% quartile deviation; 75% quartile deviation) of the patient's age, BMI (kg/m2), AHI, genioglossus CT level, geniohyoid muscle CT level, and TIAS were 51.50 years old (42.75, 62.25), 24.00 (22.00, 26.00), 24.35 (11.40, 36.10), 123.05 (90.95, 135.70), 111.20 (104.80, 116.30), and 34.65 (25.97, 40.62), respectively. The results of a multiple regression model were analyzed using Amos (Ver. 6) software where the standardized estimates of the BMI were -0.50 (p = 0.000) for the genioglossus muscle and -0.42 (p = 0.000) for the geniohyoid muscle. The standardized estimate of BMI of the distance of the TIAS was -0.55 (p = 0.001). The standardized estimate of AHI of the TIAS was -0.48 (p = 0.000).Conclusion: Consistent with the report of Saito et al., we showed evidence of fatty metamorphosis of lingual muscles of humans with effects of the TIAS and AHI.