- 著者
- 戸田 佳孝 竹村 清介 森本 忠信 小川 亮恵
- 出版者
- The Japan Society for Clinical Immunology
- 雑誌
- 日本臨床免疫学会会誌 (ISSN:09114300)
- 巻号頁・発行日
- vol.20, no.1, pp.44-51, 1997-02-28 (Released:2009-02-13)
- 参考文献数
- 18
- 被引用文献数
- 3 4
慢性関節リウマチ(以下, RA)患者に対する経口II型コラーゲン(以下, C II)の効果をHLA-DRB 1*0405遺伝子を有する群(0405群)とそれを有しない群(非0405群)に分類して評価した. 38例のRA患者を1日32mgのC IIを含む鶏軟骨スープを3カ月間投与した群(C II群)と,プラセボスープを投与した群(placebo群)に分類した. 0405/C II群は11例, 0405/placebo群は11例,非0405/C II群は9例,非0405/placebo群は9例であった. C II群では, placebo群に比べて,有意に抗ヒトC II IgG抗体値が低下し(p<0.0001),抗ヒトC II IgA抗体値が有意に増加した(p=0.003).腫脹および疼痛関節数の変化は, 0405/C II群と0405/placebo群間(腫脹関節数p=0.03,疼痛p=0.03), 0405/C II群と非0405群/C II群間(腫脹p=0.006,疼痛p=0.01)に有意差があっため, HLA-DRB 1*0405遺伝子陽性の症例では経口C II療法が有効であると結論した.
- 著者
- 小川 亮恵
- 出版者
- 関西医科大学医学会
- 雑誌
- 関西医科大学雑誌 (ISSN:00228400)
- 巻号頁・発行日
- vol.27, no.4, pp.757-777, 1975-12-20 (Released:2013-02-19)
- 参考文献数
- 26
As for the tendon lesions of the rheumatoid hand the reports of pathohistological studies are very limited except the works of Kellgren and Ball, Ehrlich et al and Potter and Kuhns. There still remain several problems not yet settled in the field of pathohi- stology, especially in the pathogenesis of tendon nodule and its relation to the development of tenosynovitis.The author made a pathohistological research using specimens removed from thirty-two patients operated on by himself, which includes the treatment of 22 hands of extensor tenosynovitis,18 fingers of digital flexor tenosynovitis and three cases of flexor tenosynovitis of the wrist. Ordinary staining such as H. E., Azan-Marolly, van Gieson, Toluidin-blue, Weigert-fibrin and Silver stainings were performed for microscopic examinat ion.The following conclusions were drawn not only from pathological findings but also from clinical features and operative findings.1. From the findings of forty-three tendon lesions the lesions could be classified into the following three groups: 1) tenosynovitis in 34,2) tendinitis in one,3) co-existence of tenosynovitis and tendinitis in 8. This suggests that the tendinitis does not always occur as a secondary product from the tenosynovitis.2. Microscopic manifestations of the findings of tenosynovitis are in many respects very similar to the synovitis of the joint of rheumatoid arthritis, but the findings of tenosynovitis are rather simple in histological manifestation as compared to joint synovitis.3. Histologically a nodule-like swelling or a nodule formation in the tissue of tendon substance is most characteristic. These nodule-like tendon lesions were classified into three types by the author,1) proliferated granuloma in epitendineum which is seen in 4 tendons,2) a. proliferated granuloma in peritendineum which is seen in 4 tendons,2) b. degenerative changes in tendon substance in one tendon. In addition to the above findings the author noticed that the inflammatory findings both in epitendineum and peritendineum were very similar to those in articular synovial tissue.