著者

永野 隆夫 渡辺 与八郎 本間 達二 祐田 泰延 山本 丈夫

出版者

公益社団法人 日本薬学会

雑誌

衛生化学 (ISSN:0013273X)

巻号頁・発行日

vol.24, no.4, pp.182-186, 1978-08-31 (Released:2008-05-30)

参考文献数

8

被引用文献数

1 2

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Effect of chlorella, which contained cadmium in its cells, designated as cadmium-containing chlorella, on rats was studied and the following facts were found : 1) When the cadmium-containing chlorella was administered to rats orally for 10 days, no significant difference in body weight from control rats was observed. However, in the case of repeated oral administration of cadmium chloride, the growth of rats was impeded significantly. 2) Cadmium concentration in organs of rats after administration of cadmium-containing chlorella for 10 days was significantly lower than that of rats administered cadmium chloride. 3) Cadmium concentration in blood after single oral administration of cadmium chloride (10 mg/kg) or cadmium-containing chlorella (10 mg/kg) was examined, and 119 ng/ml blood was found 3 hr after cadmium chloride was given but only little cadmium was detected in blood after cadmium-containing chlorella was given. 4) Urinary excretion of cadmium from cadmium-containing chlorella was significantly faster than that of rats administered cadmium chloride.

著者

山本 丈夫

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.74, no.8, pp.797-801, 1954-08-25 (Released:2010-02-19)

参考文献数

7

被引用文献数

9 12

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A strain of hyphomycetes that produces a toxic substance was isolated from a fungus that was parasitically growing on the malt feed responsible for mass death of milking cows. The fungus penetrates into malt grains from an injured section, causes morbid change in the starch and aleuron layers, to brown the tissues, and produces a metabolic products that causes marked toxicity in animals. The fungus was found to grow on a medium with a wide variety of carbon source. The morphology of the fungus on the Czapek culture medium is as follows: Vegetative mycelium, 3-5×18μ; aerial mycelium, 2μ diam.; conidiophore, 3.0-4.5×400-500μ; metulae, 3.0-5.2×6.0-10.4μ; sterigmata, 2.3-2.7×6.0-6.7μ; conidia, 2.5×3.2μ. Since the morphology and other properties of this fungus are identical with the description for Penicillium urticae Bainier in the classification by Thom (“A Manual of the Penicillia” (1949)), the fungus is now determined as that strain.