著者

小出 瑞康 関崎 敬広 山田 修一 高橋 勉 白樫 正高

出版者

一般社団法人 日本機械学会

雑誌

日本機械学会論文集B編 (ISSN:18848346)

巻号頁・発行日

vol.77, no.775, pp.702-714, 2011 (Released:2011-03-25)

参考文献数

11

被引用文献数

5 4

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The target of this research is to develop a micro electric power generator for a low cost small river monitoring device. First, the power generation by VIVs, its efficiency coefficient and the optimum condition of the generator were estimated from energy balance analysis based on the assumption that VIVs can be regarded as a resonance oscillation of a linear system. Second, water tunnel experiments were carried out and it was confirmed that the trailing vortex induced vibration (TVIV) occurs on a cruciform circular-cylinder/strip-plate system over a velocity range about 15 times wider than that of Karman vortex induced vibration (KVIV). Finally, power generation experiments were carried out by utilizing TVIV. The generator circuit consists of coils mounted on the circular cylinder vibrated by TVIV and magnets fixed on rigid supports. The generator is shown to extract energy from the water flow in the same way as a viscous damper over the expected velocity range. Although the efficiency coefficient of TVIV is lower than that of KVIV, it is more appropriate for natural rivers of which flow velocity changes greatly.

著者

中村 光利 山田 修一 松田 良介 杉本 正 中瀬 裕之

出版者

Kinki Brain Tumor Pathology Conference

雑誌

Neuro-Oncologyの進歩 (ISSN:18800742)

巻号頁・発行日

vol.19, no.1, pp.12-18, 2010-12-01 (Released:2014-04-28)

参考文献数

25

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The current practice of relying solely on microscopic examinations for histological classification of gliomas and, consequentially, determination of optimal treatment, appears to be insufficient. As a result of the increasing use of molecular markers in tumor classification, there is an emerging emphasis in the genetic profiles of distinct subtypes of glioma. These subtypes of glioma constitute distinct disease entities that evolve through different genetic pathways, and are likely to differ in prognosis and response to therapy. Status of O6-methylguaninemethyltransferase(O6-MGMT) gene is associated with the resistance to temozolomide(TMZ). We have previously found methylation or expression mosaicism of O6-MGMT in gliomas, resulting in problems on tumor sampling and respose to TMZ. An assessment of O6-MGMT methylation mosaicism in heterogeneous glioma may provide a more accurate assessment for the response to TMZ. Oligodendroglioma is recognized as a particular subtype of gliomas that shows remarkable response to chemotherapy(procarbazine + CCNU + vincristine(PCV), making their correct diagnosis important. Loss of heterozygosity(LOH) on chromosomes 1p and 19q is correlated with sensitivity to PCV chemotherapy with increased survival in anaplastic oligodendroglioma cases(WHO grade III). This article reviews biological and molecular approaches to glioma classification that have the potential to increase the efficacy of treatments for these tumors.