著者

吉田 徹 山田 等仁 津下 英明

出版者

日本結晶学会

雑誌

日本結晶学会誌 (ISSN:03694585)

巻号頁・発行日

vol.64, no.1, pp.69-76, 2022-02-28 (Released:2022-03-04)

参考文献数

20

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The iota toxin produced by Clostridium perfringens type E is a binary toxin comprising two independent polypeptides:Ia, an ADP-ribosyltransferase, and Ib, which is involved in cell binding and translocation of Ia across the cell membrane. Binary toxin family includes C. perfringens iota toxin, C. difficile CDT, C. spiroforme CST, C. botulinum C2, and B. anthracis anthrax toxin. Here we introduce the binary toxin complex structures using single-particle Cryo-EM structural analysis and the structural basis of toxin translocation system.