著者

岡田 和也 中島 公洋 荒巻 政憲 岩男 裕二郎 吉田 隆典 御手洗 義信 金 良一 小林 迪夫

出版者

Japan Surgical Association

雑誌

日本臨床外科医学会雑誌 (ISSN:03869776)

巻号頁・発行日

vol.54, no.11, pp.2749-2753, 1993-11-25 (Released:2009-01-22)

参考文献数

14

---

腫瘍径5cm以下の肝細胞癌切除68例中,多結節型13例を対象に,多中心性発生の有無や, Stage分類,治癒度分類について検討した.肉眼的進行程度は単発55例でStage I, II, IIIが10例, 24例, 21例であるのに対し,多結節型ではStage II, III, IV-Aが1例, 6例, 6例であった.また治癒度は単発例で絶対的治癒切除 (AC) 6例,相対的治癒切除 (RC) 37例,相対的非治癒切除 (RNC) 12例であるのに対し,多結節型ではRC 3例, RNC 10例であった.一方,多結節型13例中10例が多中心性発生と考えられ,その5生率は54%であった.これに対して単発例の5生率は全体で36%, Stage I, II, IIIで80%, 52%, 15%, AC, RC, RNCで100%, 43%, 22%であった.したがって多結節型肝癌は単発例に比べStageが進行したRNC症例が多いが,多中心性発生の場合には切除により比較的良好な予後が得られており,今後,多中心性発生の可能性を考慮したStage分類や治癒度分類の検討が必要と考えられた.

著者

後藤 茂 岩男 裕二郎 岩男 淳一郎 唐原 和秀 北野 正剛

出版者

一般社団法人 日本温泉気候物理医学会

雑誌

日本温泉気候物理医学会雑誌 (ISSN:00290343)

巻号頁・発行日

vol.71, no.4, pp.221-228, 2008 (Released:2010-04-30)

参考文献数

22

---

A case reportA 70-year-old male with small bowel adenocarcinoma involving retroperitoneal invasion had undergone chemotherapy after non-curative operation. However, this patient had to discontinue the first and second lines of chemotherapies within one month due to serious side effects of anti-cancer agents. Subsequently, the patient complained of severe low-back pain and there was evidence of local recurrence around the resected small intestine. Therefore, phototherapy was applied three times a week to relieve the low-back pain while the patient underwent the third line of chemotherapy. It was interesting to note that these combination therapies coincidentally ameliorated the various side effects caused by anti-cancer drugs. For one year during the third line of chemotherapy, the patient had to temporarily discontinue chemotherapy only two times when phototherapy was not available for one week due to consecutive national holidays in May and November. The quality of life of this patient was well maintained, and he only needed to be hospitalized for the last two months before he died.Epidemiological studies have shown a high incidence of cancer in people less exposed to solar rays. The sunshine “vitamin” 1 alpha, 25-dihydroxy vitamin D3 (1, 25(OH)2D3) is involved in these epidemiological studies based on the evidence that 1, 25(OH)2D3 is an antiproliferative agent that may inhibit proliferation of cancer cells in vitro and development in animals. To elucidate the synergetic effect of phototherapy in combination with chemotherapy, we assayed serum levels of 1, 25(OH)2D3 in this patient compared with those of end-stage cancer patients undergoing chemotherapy alone. Serum levels of 1, 25(OH)2D3 in this patient after receiving the combination therapies were higher than those in other cancer patients treated with chemotherapy alone.Our results indicate that phototherapy may be a good complementary therapy with chemotherapy for cancer patients.