- 著者
- 吉田 光二 星 昭夫 榑谷 和男 金井 貞 市野 元信
- 出版者
- The Japanese Cancer Association
- 雑誌
- GANN Japanese Journal of Cancer Research (ISSN:0016450X)
- 巻号頁・発行日
- vol.66, no.5, pp.561-564, 1975-10-31 (Released:2008-10-23)
- 参考文献数
- 12
Effect of substitution of 5-position of cyclocytidine with fluorine on its antitumor activity in cultured cells was examined. 5-Fluorocyclocytidine was active against cultured L-5178Y cells similar to cyclocytidine. IC50 of the compound was 0.054μg/ml. This compound inhibited thymidine incorporation into acid-insoluble fraction of the cells. Cell growth inhibition by 5-fluorocyclocytidine was reversed by deoxycytidine but not by thymidine and deoxyuridine. On the other hand, cell growth inhibition by 5-fluorouracil was reversed by thymidine and deoxyuridine. As a result, site of action of 5-fluorocyclocytidine was considered to be similar to that of cyclocytidine and not to 5-fluorouracil.
1 0 0 0 IR シトシンヌクレオシドの合成に関する研究
- 著者
- 菊川 清見 市野 元信
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.21, no.5, pp.1151-1155, 1973-05-25 (Released:2008-03-31)
- 被引用文献数
- 8 14
- 著者
- 金井 貞 小嶋 孝志 丸山 修 市野 元信
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.18, no.12, pp.2569-2571, 1970-12-25 (Released:2008-03-31)
- 被引用文献数
- 10 17