3 0 0 0 OA 酸化的ストレスと脂質過酸化
1 0 0 0 OA 細胞の脂質過酸化と老化
- 著者
- 別府 正敏 菊川 清見
- 出版者
- Japan Oil Chemists' Society
- 雑誌
- 油化学 (ISSN:18842003)
- 巻号頁・発行日
- vol.44, no.10, pp.738-750, 1995-10-20 (Released:2009-10-16)
- 参考文献数
- 110
- 被引用文献数
- 2 3
Erythrocytes undergo oxidative damage including membrane lipid peroxidation and protein oxidation during the aging process. Naturally occurring IgG autoantibody to band 3 glycoprotein of the erythrocyte membrane (anti band 3) binds to the aged erythrocytes. The IgG binding is a critical event in the removal of aged erythrocytes from the circulation since IgG-bound cells are destined to be phagocytosed by the macrophages in spleens.The selective recognition of the aged cells by the antibody occurs by the following successive mechanisms : 1) lipid peroxidation and/or SH oxidation of proteins in the membrane, 2) clustering of band 3 glycoprotein on the membrane, 3) anti-band 3 binding to the sialyl poly-N-acetyllactosaminyl saccharide chains of the clustered band 3. These events indicate that lipid peroxidation and protein oxidation are closely related to the erythrocyte aging and the mechanism of the aged cell removal from the circulation.
- 著者
- 菊川 清見 佐藤 史子 鶴尾 隆 井村 伸正 浮田 忠之進
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.16, no.6, pp.1110-1115, 1968-06-25 (Released:2008-03-31)
- 被引用文献数
- 13 23
2'-O-Benzyl-4-methylthiouridine (III) and 2'-O-benzylcytidine (VI) were obtained by respective treatment of 4-methylthiouridine (II) and cytidine (V) with benzyl bromide in the presence of sodium hydride. By this reaction, highly specific benzylation of 2'-hydroxyl group of the ribonucleosides was achieved. The both compounds (III) and (VI) could easily be converted to 2'-O-benzyluridine (IV) which is an important intermediate in the synthesis of oligonucleotide.
- 著者
- 菊川 清見 市野 元信
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.21, no.5, pp.1151-1155, 1973-05-25 (Released:2008-03-31)
- 被引用文献数
- 8 14
1 0 0 0 OA 油脂・脂質とは何か
- 著者
- 菊川 清見
- 出版者
- 公益社団法人 日本油化学会
- 雑誌
- オレオサイエンス (ISSN:13458949)
- 巻号頁・発行日
- vol.1, no.1, pp.75-82, 2001-01-01 (Released:2013-04-25)
- 参考文献数
- 4