- 著者
- 平川 善行 原田 清
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.103, no.6, pp.690-695, 1983-06-25 (Released:2008-05-30)
- 参考文献数
- 5
- 被引用文献数
- 2 2
In the previous paper, a new technique for particle size reduction of oxolinic acid (OA), a slightly soluble model drug having an acidic group in a molecule, by the crystallization through the neutralization of its alkaline solution in the presence of certain surfactant or polymer was described. The wet sieving method by the use of polycarbonate membrane filter for the evaluation of size reduction effect was also described. Various factors affecting the size reduction of OA were investigated in this paper. The results obtained were as follows ; manners of participation in various factors affecting the size reduction varied with OA concentration at crystallization, and in the case of 5 w/v% OA concentration, the influences of addition rate of hydrochloric acid solution, stirring rate, reaction temperature and concentration of hydrochloric acid were relatively low. Size reduction effects of various surfactants and polymers were investigated. All of them were effective, though differences were recognized in the extent of size reduction. It has been found that the establishment of optimal conditions to obtain the finest particles is enabled and moreover, there is a possibility to prepare the particle that have an optional particle size by regulating the various factors.
- 著者
- 平川 善行 原田 清
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.102, no.10, pp.951-959, 1982-10-25 (Released:2008-05-30)
- 参考文献数
- 26
When slightly soluble medicinal crystals are administered orally, their particle size is one of the important factors affecting the bioavailability. Therefore, it was attempted to develop a new technique of particle size reduction, in which the addition of surfactants or polymers at crystallization was examined. In order to evaluate the size reduction effect for oxolinic acid (OA), the wet sieving method was studied by the use of the polycarbonate memblane filter. This method consists of the following procedures : 1) sonication of suspension more than 10 min, 2) suction filtration of suspension after dilution, 3) measurement of the weight of the residue on each filter by the determination of OA, 4) plots of the cumulative weight of residues on a log-probability paper, followed by calculation of apparent geometric mean diameter on weight basis, 5) regulation of the volume of filtrate according to the particle size of microcrystallines. It was found that the new method studied enabled to evaluate the size reduction effect easily and accurately.