著者

原 雄二 土谷 正樹 平野 航太郎 梅田 眞郷

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.60, no.4, pp.222-226, 2020 (Released:2020-07-29)

参考文献数

20

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Fusion of myoblast cells and subsequent formation of multinucleated cells (called myotubes) are fundamental steps for generation of myofibers. In this review we focus on a role of phospholipid flippase complex ATP11A/CDC50A, a phospholipid translocase that transports phospholipids from the outer to the inner leaflets, during myotube formation. We show that translocation of phosphoatidylserine (PS) via phospholipid flippase is essential for positive regulation of PIEZO1, a mechanosensitive ion channel that is activated by membrane tension, thereby promoting RhoA/ROCK-mediated actomyosin formation that is critical for determination of myotube morphology.