著者

八木 元広 斉藤 幹央 阿部 学 宇野 勝次

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.23, no.6, pp.570-577, 1997-12-10 (Released:2011-08-11)

参考文献数

16

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We interviewed 539 patients (268 males, 271 females) treated with angiotensin converting enzyme (ACE) inhibitors to survey the incidence of dry cough caused by ACE inhibitors. In addition, we identified the latent patients with dry cough induced by ACE inhibitors and surveyed the incidence of discontinuance or change in the ACE inhibitors after the interview.The incidence of dry cough induced by the ACE inhibitors was 18.9%, and a serious dry cough was found in 4.9%. After the interview, the incidence of discontinuance or change in the ACE inhibitor administration was 20.6% in all patients with dry cough, 68.0% in the patients with a serious dry cough and 5.2% in the patients with a slight dry cough. All patients who either discontinued or changed the ACE inhibitors soon stopped soffering from dry cough. These results indicate that dry cough caused by the ACE inhibitors may be a clinically severe problem. Moreover, the detection and suitable treatment of latent patients with dry cough induced by ACE inhibitors is also important in order to perform proper drug therapy.