著者

虎石 顕一 中村 規子 由井薗 陽一 森 真弓 山田 正紀 高橋 司 黒川 美智子

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.24, no.5, pp.479-483, 1998-10-10 (Released:2011-08-11)

参考文献数

12

被引用文献数

12 9

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In order to improve children's compliance in taking bitter medicine, a gel base confectionery, which immediately changes into a jelly from after adding a special liquid, was used to mask the characteristic taste of the medicament. In pre-clinical trials, this jelly was evaluated by six adult volunteers who all reported the bitter taste to distinctly disappear in the jelly-formed quinia compared to a the powder of this medicine. Furthermore, we confirmed no comparable changes to exist in the serum levels of acetaminophene between acetaminophene alone and the gelbasemedicament mixture by oral administration. A clinical trial in three pediatric patients, who usually refuse medication because the bitter taste of the drugs, resulted in a 100% drug compliance for these children.

著者

本田 義輝 中野 眞汎

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.23, no.3, pp.219-224, 1997-06-10 (Released:2011-08-11)

参考文献数

7

被引用文献数

8 11

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The adsorption characteristics of various adsorbates by spherical charcoal (Kremezin ®) were studied in vitro and then compared with those of powdered medical charcoal. Medical charcoal adsorbs substances with molecular weights ranging from several hundred daltons to several thousand daltons. Kremezin, however, adsorbs only low molecular weight substances with molecular weights of up to several hundred daltons. Therefore, the adsorption selectivity of Kremezin, which is related to the molecular weight of adsorbate, seemed to contribute to the specific pharmacological action of this drug under clinical conditions. In batch adsorption tests for various amines, amino acids and organic acids with molecular weightsof from 45 to 251, both adsorbents showed similar behaviors. An increase in the size of the adsorbate molecule enhanced the degree of adsorption, especially in compounds that are analogs. The molecular structure also seemed to be an important factor in the adsorption phenomena; an aromatic ring tended to increase the adsobability while the amino group, carboxyl group and hydroxyl group all showed a decrease in adsorbability.

著者

山岡 桂子 近森 温子 阿部 由明 所 安夫

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.2, no.2, pp.111-116, 1976 (Released:2011-08-11)

参考文献数

2

被引用文献数

1

---

The number of glass particles arising in parenteral solution upon cutting of ampules was determined with use of 5-ml transparent and brown ampules. Cutting by “cracking” produced most satisfactory results of all methods devised. It was found as a result of the investigation by X-ray fluoroscopy that the solution contained in the ampules was almost completely free from particles from a file used for cutting. Mice injected intravenously into the tail with large amount of glass particles from ampule died of shock due to multiple pulmonary thrombosis. Tubercles caused by glass particles were observed in mice which survived the experiment without acute symptoms.

著者

大谷 道輝 佐久間 博文 高山 和郎 小滝 一 澤田 康文 伊賀 立二

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.23, no.1, pp.11-18, 1997 (Released:2011-08-11)

参考文献数

24

被引用文献数

11 9

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Six kinds of well-prescribed admixtures of commercially available ointments and/or creams were selected from the prescribed sheets in our hospital. The skin permeability of corticosteroid from these admixtures was investigated by in vitro experiments using hairless mice skin. The permeability of corticosteroid through skin after adaptation of corticosteroid creams (Lidomex®) alone was approximately 9-fold larger as compared with that of the ointments only.The pemeability of conicosteroid in the admixture of Nedsona Universal®cream or Lidomex®ointment and urea ointments respectively was 3-and 5-fold larger than that from the cream and ointments alone. However, urea ointments did not influence the permeability of the drug in Lidomex®creams.This suggested that the w/o-type urea ointments more greatly enhanced the permeability of corticosteroid as compared with the o/w type urea ointments. The extent of the stability of the emulsion after mixing was related to the permeability. These results suggest that admixing ointments and/or creams should be carried done among bases having similar physicochemical characteristics.

著者

丸山 修治 三浦 基靖 等 浩太郎 平野 久美 青野 浩直 高井 伸彦 川上 純一

出版者

一般社団法人 日本医療薬学会

雑誌

日本医療薬学会年会講演要旨集 23 (ISSN:24242470)

巻号頁・発行日

pp.244, 2013-08-28 (Released:2019-01-19)

著者

嶋崎 幸也 細谷 和良 田子 兼重 瀬尾 元一郎

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.19, no.4, pp.295-302, 1993-08-20 (Released:2011-08-11)

参考文献数

22

被引用文献数

2 3

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The sensitivity to drugs, the pH in the medium of extract from intestinal content (MEIC) and the utilization of carbohydrates in the strain isolated from multi-drug-resistant Enterococcus preparations (RP) were compared with those in the strain isolated from conventional Enterococcus prepations (CP). The RP showed higher resistance to penicillin and macrolide antibiotics than the CP, but less resistance to quinolone antibiotics. In the MEIC, the CP decreased the pH more markedly than the RP. Regarding utilization of carbohydrates, both the RP and CP had the similar patterns to the catabolisms of Enterococcus faecium, but different catabolisms were observed between RP and CP.

著者

八木 元広 斉藤 幹央 阿部 学 宇野 勝次

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.23, no.6, pp.570-577, 1997-12-10 (Released:2011-08-11)

参考文献数

16

---

We interviewed 539 patients (268 males, 271 females) treated with angiotensin converting enzyme (ACE) inhibitors to survey the incidence of dry cough caused by ACE inhibitors. In addition, we identified the latent patients with dry cough induced by ACE inhibitors and surveyed the incidence of discontinuance or change in the ACE inhibitors after the interview.The incidence of dry cough induced by the ACE inhibitors was 18.9%, and a serious dry cough was found in 4.9%. After the interview, the incidence of discontinuance or change in the ACE inhibitor administration was 20.6% in all patients with dry cough, 68.0% in the patients with a serious dry cough and 5.2% in the patients with a slight dry cough. All patients who either discontinued or changed the ACE inhibitors soon stopped soffering from dry cough. These results indicate that dry cough caused by the ACE inhibitors may be a clinically severe problem. Moreover, the detection and suitable treatment of latent patients with dry cough induced by ACE inhibitors is also important in order to perform proper drug therapy.

著者

杉山 宏之

出版者

一般社団法人 日本医療薬学会

雑誌

日本医療薬学会年会講演要旨集 20 (ISSN:24242470)

巻号頁・発行日

pp.199, 2010-10-25 (Released:2019-01-19)

著者

保田 静江 武藤 正 中岡 洋子 山下 朋子 岡村 好孝 柏木 哲夫 内藤 俊一

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.8, no.3, pp.222-228, 1982-08-20 (Released:2011-08-11)

参考文献数

4

---

Brompton mixture was used for reducing the pain in cancer patients at the terminal stage. The mixture was effective in treatment and caused no adverse reactions, such as cloudiness of consciousness, personality deviation, and psychological dependency and tolerance. Some patients were able to take the mixture orally until the day just before death. The effectiveness of the Brompton mixture was investigated on 34 patients. It was considered that the increase in dose to reduce a pain might be due to the increase of pain associated with exacerbation of cancer and/ or malabsorption of morphine rather than drug tolerance to morphine. Morphine concentration in plasma of a patient with pain well-controlled by the mixture was about 0.4μg/ml. Adverse reactions of the Brompton mixture were decreased in parallel with the use of prochlorperazine and other drugs.

著者

森山 祐輔 有森 和彦 中野 眞汎

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.18, no.3, pp.245-251, 1992-06-20 (Released:2011-08-11)

参考文献数

11

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The statistics indicates that the constitution of children, which includes height and body weight, has developed during the last 40 years.Therefore, we investigated that body surface area of children at present for every age which was calculated with Fujimoto's formula was greater than that in 1948.So we reexamined pediatric dose obtained from Augsberger's I, Augsberger's II, Young's, and Fujimoto's formula.The pediatric dose ratio based on body surface area in 1948 much more corresponded with the dose ratio obtained from the Augsberger's II formula.On the other hand, the pediatric dose ratio based on body surface area for every age in 1987 was shifted to higher dose ratio compared with that obtained from the Augsberger's II formula. The pediatric dose ratios obtained from three formulas except Fujimoto's formula indicated lower dose ratio than that obtained from Fujimoto's formula.Furthermore, under the age of five, pediatric dose ratio calculated from Fujimoto's formula was higher than that calculated from Du Bois's formula.The difference between the two dose ratios was larger as the age of children was lower.Consequently, considering big change in the constitution of children during the last 40 years, there may be a possibility to estimate lower pediatric dose than the dose which was required in the present children, if the pediatric dose was eviluated with Augsberger's II formula.

著者

有森 和彦 宮崎 万理 若山 香都美 弟子丸 恵実 中野 眞汎

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.16, no.6, pp.380-384, 1990-12-20 (Released:2011-08-11)

参考文献数

13

著者

大塚 充 澤田 真嗣 大坪 達弥 堀内 あす香 小森 玉緒 西川 靖之 三上 正

出版者

一般社団法人 日本医療薬学会

雑誌

日本医療薬学会年会講演要旨集

巻号頁・発行日

vol.23, 2013

著者

青山 敏信 樋口 駿 堀岡 正義

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.4, no.2, pp.74-82, 1978 (Released:2011-08-11)

参考文献数

10

---

Fourteen lots of tablets, capsules and granules of commercial lysozyme chloride preparations, manufactured by six differerent companies, were evaluated for their pharmaceutical qualities. Significant difference of in vitro dissolution rate was noted between these products, when tested with 1st and 2nd fluids in the disintegration test of J. P. IX as dissolution media in the rotation method of U. S. P. XIX. The dissolution rate may have relationship with clinical effect of the products. By disc electrophoresis, impure protein was found to be contained in the preparations of all but one manufacturer. New quantitative analytical method by means of the area of bacteriolysis on gel-plate was developed in this study. The new method proved to produce results same as those obtained by the conventional method on the basis of the change in turbidity depending on bacteriolysis.

著者

宇佐美 英治 水野 政義 瀬山 義幸

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.24, no.2, pp.173-178, 1998 (Released:2011-08-11)

参考文献数

21

被引用文献数

1 1

---

The superoxide anion scavenging activity of traditional Chinese medicines (Kampo) was estimated by the nitrate and nitrobluetetrazolium methods. No.15 and 34 revealed a strong superoxide anion scavenging activity and No.1, 7, 19, 25 and 45 revealed a relatively strong superoxide anion scavenging activity by nitrate method. On the other hand the nitrobluetetrazolium method revealed a relatively strong activity in No.1, 15, 25, 45 and 96. In particular, both methods denoted a relatively strong superoxide anion scavenging activity in No.1, 15, 25 and 45. These results suggest that the superoxide anion scavenging activity of each component accumulatively contribute to those Kampo medicines and might play an anti-inflamatory effect and “Ku-Oketsu” (improved blood circulation) effect in these medicines.

著者

奥村 学 瀬尾 量 長沼 広子 日高 慎二 児玉 裕文 前田 共秀 橋本 強 鶴岡 道雄

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.17, no.3, pp.162-166, 1991-06-20 (Released:2011-08-11)

参考文献数

4

---

A new computerized system for making of drug envelope has been developed in Miyazaki Medical College Hospital Department of Pharmacy.Although such system has been already developed, most of system were not sufficient for labor-saving.This developed system has no need to put label on drug envelope, and to separate drug envelope.And the time to produce prescription and drug envelope was half as much as that of writing by hand.Hence We can use free time that we got by our system for other work.At all points, our system make a great contribution to labor-saving at hospital pharmacy.

著者

前田 恵里

出版者

一般社団法人 日本医療薬学会

雑誌

日本医療薬学会年会講演要旨集 第32回日本医療薬学会年会 (ISSN:24242470)

巻号頁・発行日

pp.632-636, 2022-09-23 (Released:2022-11-18)

著者

福島 雅典

出版者

一般社団法人 日本医療薬学会

雑誌

日本医療薬学会年会講演要旨集 13 (ISSN:24242470)

巻号頁・発行日

pp.125, 2003-09-01 (Released:2019-01-19)

著者

河田 興

出版者

一般社団法人 日本医療薬学会

雑誌

日本医療薬学会年会講演要旨集 20 (ISSN:24242470)

巻号頁・発行日

pp.199, 2010-10-25 (Released:2019-01-19)

著者

芳原 準男 外間 惟夫 亀谷 浩昌 大城 進

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.25, no.3, pp.319-322, 1999-06-10 (Released:2011-08-11)

参考文献数

9

---

The drug interaction between sodium valproate (VPA), an anticonvulsant, and faropenem sodium (FRPM), a new penem antibiotic drug, was studied in rats. No significant change was observed in the plasma VPA concentration when compared with the control after the administration of VPA (TOO mg/kg per oral) simultaneously with FRPM (600 mg/kg per oral).

著者

五土嵐 正博 黒岩 朝子 林 昌洋 灰田 美知子 峯村 信嘉 高木 英爾 西山 信一郎 百村 伸一

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.26, no.2, pp.207-211, 2000 (Released:2011-08-11)

参考文献数

17

被引用文献数

3 3

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We experienced a serious interaction between miconazole gel and warfarin. The patient had just undergone an aortic and mitral value replacement and thus was medicated with warfarin at a dosage according to the International Normalized Ratio (INR) of about 2.0-2.5. He was prescribed miconazole gel 400 mg/day for thrush induced by steroid for asthma. About two weeks later, he showed bleeding in the mouth and underwent a medical examination. His INR was higher than the upper of measurement limit and so he was immediately hospitalized. Vitamin K was given, miconazole gel and warfarin ware stopped. Two weeks later, his INR was less than 3.0 and thus the warfarin was restarted. But his warfarin dose was less than one third of dosethat had been given before hospitalization.The interaction between miconazole gel and warfarin that we experienced by our patient while was as serious as the reports from abroad.