著者

斎藤 烈 杉山 弘

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.40, no.8, pp.735-743, 1982-08-01 (Released:2009-11-13)

参考文献数

47

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The molecular recognition of DNA by small molecules including bisintercalators has been described. Site-specific chemical reactions of DNA are next reviewed. These include i) reactions of DNA with oxygen-dependent antibiotics such as bleomycin, neocarzinostatin and camptothecin, and ii) single strand cleavage induced by artificial compound-metal-O2 systems. Sequence specific photoreaction between DNA and psoralenes is briefly discussed. A new method for selective removal of thymine from DNA utilizing photochemical reaction is also described in detail.