著者

早川 栄治

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.36, no.4, pp.177-182, 2011 (Released:2011-12-13)

参考文献数

8

被引用文献数

1 1

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Softgel capsules consist of a gelatin based shell or vegetable origin materials such as starch and carrageenan. They can be filled with liquids or pastes. Dynamic nature of the soft capsules affected by atmospheric condition or filled liquid is considered in view of the surface interaction.

著者

中垣 正幸 嶋林 三郎 早川 栄治 小槻 節

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.99, no.6, pp.618-627, 1979-06-25 (Released:2008-05-30)

参考文献数

11

被引用文献数

5 3

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The amounts of both Ca2+ and Na+, x and y, respectively, bound to C-type chondroitin sulfate (Chs) from an aqueous solution of CaCl2 mixed with NaCl were obtained by the membrane equilibrium method. To estimate x and y under the effect of the Donnan equilibrium, [Ca2+] and [Cl-] for both sides of the dialysing tube and [Chs] for the inner side were analysed. The binding isotherm for Ca2+ was of the Langmuir type, and both x and kCa2+, the binding constant for Ca2+, decreased with ionic strength, J. On the other hand, the binding isotherm for Na+ was not of the Langmuir type but its shape was explained as the competitive adsorption of the two components, Na+ and Ca2+, because Ca2+ binds more strongly to Chs than Na+ and, therefore, the effect of coexistence of Ca2+ with Na+ cannot be neglected when the Na+ binding is examined. It was also suggested that y and kNa+ decreases with J when the amount of the occupied site by the Ca2+ is kept constant at x. The degree of the ionization, z, of Chs was found to be 0.40-0.41 for Na2Chs and 0.20-0.21 for CaChs by this membrane equilibrium method assuming x+y+z=1. These values coincide with those obtained from the vapour pressure osmometry by the authors and with the literature values calculated with considering the Manning theory.