著者

木村 雅行 池田 雅和 柴田 英之 池田 祥子 松本 圭介

出版者

日本食品化学学会

雑誌

日本食品化学学会誌 (ISSN:13412094)

巻号頁・発行日

vol.11, no.2, pp.67-74, 2004-09-28 (Released:2017-12-01)

参考文献数

13

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To estimate the laxative threshold (LT) and 50% effective dose (ED50) for diarrhea of a galactooligosaccharide (GOS) syrup (43% GOS ; 9.5% lactose ; 18% glucose ; 6.3% galactose ; 24% water), we asked 24 healthy subjects (12 men and 12 women ; age, 20 to 58 years ; weight, 39.0 to 96.0 kg) to ingest 190mL of aqueous solutions containing 5 different amounts (11.7,23.3,46.7, 70.0, 93.3g) of the syrup once every week from a low content to high one. Of the 24 subjects, 16 had diarrhea after ingestion of any test beverage. We estimeted the LT and ED50 of the GOS syrup by using a regression equation between the minimal dose levels (g/kg body weght) of the syrup caused diarrhea and the cumulative incidence of diarrhea. For the entire population, the estimated LT was 0.68 g/kg (0.30 g/kg as GOS) and the ED50 was 1.39 g/kg (0.60 g/kg as GOS). For men, the LT and ED50 were 0.65 g/kg and 1.13 g/kg, respectively, as compared with 0.90 g/kg and 1.50 g/kg for women. An increased frequency of bowel movements seemed to increase the incidence of diarrhea. The other abdominal symptoms reported were borborygmus (88%), flatus (58%), and abdominal distention (46%), all of which were transient, as was diarrhea. We also examined the safety of ingesting daily near amount of LT of the GOS syrup (15 g/person daily as GOS) for 2 weeks in 20 healthy adults. Although this dose increased the occurrence of abdominal gas in these subjects, the prevalence of diarrhea was unchanged as compared with that for the placebo beverage. These results show that the GOS syrup is safe even in repeated intake for near amount of LT.

著者

木村 雅行 長南 治 高橋 理恵 大橋 あけみ 新井 ゆみ 早川 和仁 笠羽 恵子 石原 知代子

出版者

日本食品化学学会

雑誌

日本食品化学学会誌 (ISSN:13412094)

巻号頁・発行日

vol.9, no.1, pp.1-6, 2002-05-31

被引用文献数

2

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We examined the effects of a new type of fermented milk containing γ-aminobutyric acid (FMG), made by a co-culture of Lactobacillus casei and Lactococcus lactis, on normal blood pressure and the abdominal symptoms of healthy adults. Administration of FMG (100mL/d) for 8 weeks or excess volumes (300mL/d) for 2 weeks failed to induce any changes in normal blood pressure and heart rate. Administration of excess volumes of FMG did not result in diarrhea. No remarkable changes in hematological and biochemical indices were observed after 8 weeks' ingestion and 2 weeks' excess intake of FMG. In conclusion, our results show that FMG is a safe fermented milk product.

著者

梶本 修身 平田 洋 中川 聡史 梶本 佳孝 早川 和仁 木村 雅行

出版者

Japanese Society for Food Science and Technology

雑誌

日本食品科学工学会誌 : Nippon shokuhin kagaku kogaku kaishi = Journal of the Japanese Society for Food Science and Technology (ISSN:1341027X)

巻号頁・発行日

vol.51, no.2, pp.79-86, 2004-02-15

被引用文献数

13 43

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WHO/ISHの血圧の定義・分類で正常高値に該当する者を対象として,FMGのプラセボを対照とした12週間の2重盲検長期摂取試験を実施したところ,以下のことが明らかとなった.<br>被験飲料群では,収縮期血圧が摂取8週間後に有意に低下し,摂取12週間後まで継続して安定した降圧が認められた.また,拡張期血圧は摂取12週間後に有意に低下した.<br>試験期間中,血液および尿検査値の異常はみられず,また,診察所見および自覚的所見において,被験飲料摂取によると思われる重篤な副次的作用は認められなかった.<br>したがって,FMGは,正常高値血圧者に対して,収縮期血圧および拡張期血圧の降下作用を有し,かつ高い安全性を有することが明らかとなった.