著者

柴田 丸 吉田 玲子 本橋 幸子 福島 正子

出版者

公益社団法人日本薬学会

雑誌

薬学雑誌 (ISSN:00316903)

巻号頁・発行日

vol.93, no.12, pp.1660-1667, 1973-12

被引用文献数

8

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Crude saikosides did not affect the LD_<50> value of sodium hexobarbital in mice. It also exerted a protective effect on the pylorus-ligated ulcer of the rat with inhibiting gastric secretion. The cure of chronic ulcer produced by the injection of dilute acetic acid into the rat gastric wall was promoted by crude saikosides. Saikogenin A showed a potent effect of decreasing spontaneous motor activities of the mice treated with methamohetamine hydrochloride. It had a significant antitussive, hypothermic, and antipyretic effect, and inhibition of acetic acid-induced writhing responses. In addition, salikogenin A strongly reduced a carrageenin-induced rat paw edema, without any local irritaition by topical application. On the contrary, only analgesic effect was found in the syrupy residue. The significance of these pharmacological results was discussed.