著者

柴田 丸 吉田 玲子 本橋 幸子 福島 正子

出版者

公益社団法人日本薬学会

雑誌

薬学雑誌 (ISSN:00316903)

巻号頁・発行日

vol.93, no.12, pp.1660-1667, 1973-12

被引用文献数

8

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Crude saikosides did not affect the LD_<50> value of sodium hexobarbital in mice. It also exerted a protective effect on the pylorus-ligated ulcer of the rat with inhibiting gastric secretion. The cure of chronic ulcer produced by the injection of dilute acetic acid into the rat gastric wall was promoted by crude saikosides. Saikogenin A showed a potent effect of decreasing spontaneous motor activities of the mice treated with methamohetamine hydrochloride. It had a significant antitussive, hypothermic, and antipyretic effect, and inhibition of acetic acid-induced writhing responses. In addition, salikogenin A strongly reduced a carrageenin-induced rat paw edema, without any local irritaition by topical application. On the contrary, only analgesic effect was found in the syrupy residue. The significance of these pharmacological results was discussed.

著者

吉田 玲子 浅川 和夫 佐藤 公典 栗坂 昌宏 北村 守彦

出版者

日本失語症学会 (現 一般社団法人 日本高次脳機能障害学会)

雑誌

失語症研究 (ISSN:02859513)

巻号頁・発行日

vol.4, no.2, pp.664-670, 1984 (Released:2006-08-04)

参考文献数

14

被引用文献数

2 3

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A case of semantic aphasia (Luria) with difficulty in understanding logico-grammatical relations was reported. The patient, 28-year-old left-handed woman, was injured in a traffic accident in the right parieto-occipital area. After fifteen months of recuperation, she was noticed to suffer from mild word-finding difficulty, agraphia, acalculia, minimum right-left discrimination deficit and disturbance of logico-grammatical operations, in the context of excellent verbal I. Q. on the WAIS Test and almost normal performance on the Token Test and other syntax tests. Spatial organization and representation ability showed some decline. Difficulty of understanding logico-grammatical relations became apparent mostly in the case of double comparative constructions or triple constructions which required the subject, for instance, to draw a circle to the right of a triangle and to the left of a square. To decipher these logico-grammatical constructions according to grammatical rules, it seemed neccessary for the subject to consider the elements of the sentence simultaneously in order to know which is the main element acting as the basic point of judgment, to represent mentally the relation of elements as a spatial constellation, and to reverse mentally the word order in the sentence. It was difficult for the patient to meet these requirements.