- 著者
- 安田 行寛 東郷 常夫 采見 憲男 渡辺 昭治 播磨 耕介 鈴江 崇志
- 出版者
- 公益社団法人 日本化学療法学会
- 雑誌
- CHEMOTHERAPY (ISSN:00093165)
- 巻号頁・発行日
- vol.21, no.6, pp.1171-1178, 1973-08-25 (Released:2011-03-08)
- 参考文献数
- 9
- 被引用文献数
- 1
N1-(2-Tetrahydrofuryl)-5-fluorouracil (FT-207), a new antimetabolic anticancer agent synthesized in USSR, was studied on antimicrobial activity in vitro and distribution, excretion and metabolism in vivo.The results obtained were as follows.1) Antimicrobial activityFT-207 showed fairly active against Micrococcus flavus ATCC 10240, Sarcina lutea PCI 1001, Staphylococcus epidermidis and Staphylococcus aureus 209 P, but in general the activity was inferior to that of 5-FU.2) DistributionBy the intravenous administration of FT-207, 400mg/kg, in normal and AH-130 bearing rats, the concentration of FT-207 in serum and tissues maintained measurably until 16-24 hours.On the other hand, the active substances (5-FU, etc.) from FT-207 detected at 1-4 hours and peaked at 4-16 hours in tissues.3) Urinary excretionFT-207 and its active substances were excreted in urine for a long time, and the recoveries of FT-207 for 48 hours in rats, mice and rabbits were 12-18%.4) MetabolismIn normal and AH-130 bearing rats, the main active substance from FT-207 administrated intravenously was 5-FU.
- 著者
- 安田 行寛 東郷 常夫 采見 憲男 渡辺 昭治 播磨 耕介 鈴江 崇志
- 出版者
- 公益社団法人 日本化学療法学会
- 雑誌
- 日本化学療法学会雑誌 (ISSN:00093165)
- 巻号頁・発行日
- vol.21, no.6, pp.1171-1178, 1973
N<SUB>1</SUB>-(2-Tetrahydrofuryl)-5-fluorouracil (FT-207), a new antimetabolic anticancer agent synthesized in USSR, was studied on antimicrobial activity <I>in vitro</I> and distribution, excretion and metabolism <I>in vivo</I>.<BR>The results obtained were as follows.<BR>1) Antimicrobial activity<BR>FT-207 showed fairly active against <I>Micrococcus flavus</I> ATCC 10240, <I>Sarcina lutea</I> PCI 1001, <I>Staphylococcus epidermidis</I> and <I>Staphylococcus aureus</I> 209 P, but in general the activity was inferior to that of 5-FU.<BR>2) Distribution<BR>By the intravenous administration of FT-207, 400mg/kg, in normal and AH-130 bearing rats, the concentration of FT-207 in serum and tissues maintained measurably until 16-24 hours.<BR>On the other hand, the active substances (5-FU, <I>etc</I>.) from FT-207 detected at 1-4 hours and peaked at 4-16 hours in tissues.<BR>3) Urinary excretion<BR>FT-207 and its active substances were excreted in urine for a long time, and the recoveries of FT-207 for 48 hours in rats, mice and rabbits were 12-18%.<BR>4) Metabolism<BR>In normal and AH-130 bearing rats, the main active substance from FT-207 administrated intravenously was 5-FU.