3 0 0 0 OA 細胞はゆらぎに満ちている:反応ノイズの生成,増幅と伝搬
- 著者
- 柴田 達夫
- 出版者
- 一般社団法人 日本生物物理学会
- 雑誌
- 生物物理 (ISSN:05824052)
- 巻号頁・発行日
- vol.46, no.4, pp.194-200, 2006 (Released:2006-07-25)
- 参考文献数
- 12
- 被引用文献数
- 1 2
Stochasticity of chemical reaction is particularly prominent in small systems, such as cells. Recent experimental and theoretical studies reveal that stochastic cellular reactions generate fluctuations, which affect the behaviors of downstream reactions. Here, I show how large each reaction generate fluctuation, and how large the fluctuation is amplified in the downstream reaction. I discuss the possibility that such propagating fluctuations convey information about reaction networks.
2 0 0 0 OA サイズの発生学―濃度勾配のスケーリング―
- 著者
- 猪股 秀彦 柴田 達夫
- 出版者
- 一般社団法人 日本生物物理学会
- 雑誌
- 生物物理 (ISSN:05824052)
- 巻号頁・発行日
- vol.54, no.3, pp.140-145, 2014 (Released:2014-05-27)
- 参考文献数
- 12
The Spemann organizer secretes the anti-BMP protein Chd, and provides dorsal positional information by inactivating the ventralizing signals BMPs in a spatially graded manner. Several studies have shown that a morphogenetic field exhibits a strong tendency of self-regulation. For instance, when a blastula embryo is bisected across the D-V axis, the dorsal half develops into a well-proportioned half-size embryo, which retains a nearly normal DV ratio. These observations indicate that the BMP activity gradient is dynamically and flexibly regulated in response to changes of the embryonic size. Here we demonstrate that the auto-regulatory loop of Chd degradation plays a decisive role in scaling.