著者

桜井栄一著

出版者

朝日ソノラマ

巻号頁・発行日

1983

著者

飯塚 幸澄 桜井 栄一 田中 頼久

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.121, no.5, pp.365-369, 2001-05-01 (Released:2002-09-27)

参考文献数

12

被引用文献数

8 10

---

The antidiabetic effect of hot water extracts from Folium Mori was investigated in GK rat; one of the animal models of non-insulin dependent diabetic mellitus types. Folium Mori extracts (150 mg/kg) significantly reduced the blood glucose of GK rat from 203.8±29.8 to 138.5±21.2 mg/dl at 14 days after oral administration. However, in normal rats, blood glucose and insulin levels were not changed by treatment with Folium Mori. The Folium Mori also decreased blood glucose and improved glucose tolerance at 14 days after repeated administration in GK rats. The Folium Mori treatment significantly increased glucose metabolism in the glucose clamp test for GK rats. These results suggest that Folium Mori has quite unique properties such as raising insulin sensitivity and improving insulin resistance.

著者

丹羽 弘司 引地 登 桜井 栄一 植田 公孝 福勢 元

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.100, no.11, pp.1118-1126, 1980-11-25 (Released:2008-05-30)

参考文献数

30

被引用文献数

2

---

Effects of maltitol and mannitol on the gastrointestinal absorption of acetaminophen, sulfisoxazole and riboflavine in mice were investigated. When drugs were orally administered with maltitol or mannitol, and 2 hr after maltitol or mannitol was orally given in mice (in diarrhea), the blood levels of drugs became lower than that in the control, and drug absorption was inhibited. It was suggested that these results were not caused by molecular interaction between drugs and sugar alcohols, but by the action of maltitol and mannitol which accelerated small intestinal motility, secretion and vascular permeability in the intestinal membrane. These changes may be mediated by biogenic amine, serotonin, histamine and polyamines in the small intestine.