著者

樋口 佳則 青柳 京子 岡原 陽二 和泉 允基

出版者

医学書院

巻号頁・発行日

pp.799-809, 2021-07-10

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Point・淡蒼球刺激術は,パーキンソン病,ジストニアなどの運動過多を生じる不随意運動症の治療オプションである.・淡蒼球の内側には内包,腹側には視索が存在し,淡蒼球内節(GPi)の腹外側部2/3が感覚運動領域で視床へ投射する.・パーキンソン病症例では,視床下核(STN)刺激との違い(ジスキネジア抑制効果など)を理解し選択する.

著者

小野 純一 樋口 佳則 町田 利生 松田 信二 石毛 聡 永野 修 田島 洋佑

出版者

一般社団法人 日本脳卒中の外科学会

雑誌

脳卒中の外科 (ISSN:09145508)

巻号頁・発行日

vol.43, no.2, pp.118-124, 2015 (Released:2015-05-27)

参考文献数

19

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The natural history of intracranial arterial dissection is not well known. This study was conducted to elucidate the serial changes of radiographic findings and the long-term outcomes in both hemorrhagic and non-hemorrhagic patients who underwent intracranial vertebrobasilar artery dissection.Among 200 patients who underwent intracranial arterial dissection of the vertebrobasilar system, 99 (49.5%) were conservatively managed. These patients were divided into two groups: the hemorrhagic group (H, subarachnoid hemorrhage; n = 24 patients) and non-hemorrhagic group (NH, ischemia or headache; n = 75). Age, site of dissection, initial radiological findings and serial changes, follow-up period, and long-term outcome were analyzed. Outcomes were evaluated using the Glasgow Outcome Scale.Results: The median ages were 54 and 52 years in the H and NH groups, respectively. In both groups, the vertebral artery was most commonly affected, followed by the basilar artery. Regarding radiographic findings, the pearl-and-string sign was the most common initial finding in the H group. Conversely, tapering, narrowing, or occlusion was the most common finding in the NH group. As for serial changes in radiographic findings, no change was most frequent in both groups, followed by improvement. These changes mostly occurred within a few months in the H group but over several years in the NH group. The mean follow-up periods were 7.2 and 5.7 years in the H and NH groups, respectively. Regarding long-term outcomes, in the H group, 15 patients (62.5%) had a good recovery, and 7 (29.2%) died. In the NH group, 58 patients (77.5%) recovered, and 7 (9.3%) died. The cause of poor outcome was initial hemorrhage or subsequent rupture in the H group. Poor outcomes in the NH group were primarily due to systemic problems.These results demonstrate the long-term radiological changes and outcomes associated with the intracranial arterial dissection of the vertebrobasilar system. However, these findings are insufficient to argue the natural history of this disease because patients who received surgical treatment were excluded from this study.