著者

織部 元廣 永野 修司 立川 裕史 塚川 博志

出版者

一般社団法人 日本臨床リウマチ学会

雑誌

臨床リウマチ (ISSN:09148760)

巻号頁・発行日

vol.19, no.1, pp.24-30, 2007-03-30 (Released:2016-12-30)

参考文献数

25

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We evaluated the effects of fasting on symptoms in 15 fibromyalgia syndrome (FMS) patients and 6 rheumatoid arthritis (RA) patients over 10 days in an open, non-randomized, controlled study. The results revealed significantly greater improvement (p<0.05) in the visual analogue scale (VAS) of pain in the 13 out of 15 FMS patients who completed the fasting versus the 6 RA patients in the10 days duration. Both groups reduced in body weight with a significant average loss of 5 kg (p<0.01) respectively. The appearance of Ketone bodies in urine did not seem to affect the level of pain reduction. Obviously, the VAS score of the RA group showed a different pattern in the10days duration compared to the FMS group. The RA group showed a relatively “straight line pattern”. That is within the10 days, relatively insignificant fluctuation in the VAS was observed within the entire group. On the other hand, almost every one in the FMS group showed a “fluctuated line pattern” of aggravation, and after that the VAS score rapidly decreased. As a marked decrease in the VAS score occurred when starvation appeared, it suggested the sensation of starvation played an important role in the disappearance of bodily pains with the FMS group. It is therefore concluded that fasting therapy has a beneficial effect on FMS symptoms, as compared to the insignificant effect on RA symptoms, at least in a short period such as 10 days.

著者

島田 潤一郎 松田 信二 町田 利生 永野 修 本間 甲一 沖山 幸一 小野 純一

出版者

一般社団法人 日本脳卒中学会

雑誌

脳卒中 (ISSN:09120726)

巻号頁・発行日

vol.31, no.4, pp.222-226, 2009

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超急性期脳梗塞に対する血栓溶解療法において,初診時軽症または急速な症状改善のみを理由に適応除外された症例の予後を検討した.【方法】2002年4月から2007年9月に発症2時間以内に来院した脳梗塞症例のうち,初診時軽症あるいは急速な症状改善のみを理由に経動脈的又は経静脈的血栓溶解療法から適応除外された70例を対象とした.退院時予後不良(modified Rankin scale &ge;3)の割合および予後不良に関与する因子を統計学的に検討した.【結果】対象は男48,女22,平均年齢70.3才.初診時軽症による適応除外45例中3例(6.7%),急速症状改善による適応除外25例中8例(32%)が予後不良であり,症状改善を理由とした群で高率であった(Fisher直接法,p=0.0128).【結論】急速な症状改善のみを理由とした適応除外例では退院時予後不良の割合が高く,除外決定には慎重を期すべきである.<br>

著者

織部 元廣 永野 修司 立川 裕史 塚川 博志

出版者

一般社団法人 日本臨床リウマチ学会

雑誌

臨床リウマチ (ISSN:09148760)

巻号頁・発行日

vol.19, no.1, pp.24-30, 2007

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&nbsp;&nbsp;&nbsp;&nbsp;We evaluated the effects of fasting on symptoms in 15 fibromyalgia syndrome (FMS) patients and 6 rheumatoid arthritis (RA) patients over 10 days in an open, non-randomized, controlled study. The results revealed significantly greater improvement (p<0.05) in the visual analogue scale (VAS) of pain in the 13 out of 15 FMS patients who completed the fasting versus the 6 RA patients in the10 days duration.<br>&nbsp;&nbsp;&nbsp;&nbsp;Both groups reduced in body weight with a significant average loss of 5 kg (p<0.01) respectively. The appearance of Ketone bodies in urine did not seem to affect the level of pain reduction. Obviously, the VAS score of the RA group showed a different pattern in the10days duration compared to the FMS group.<br>&nbsp;&nbsp;&nbsp;&nbsp;The RA group showed a relatively "straight line pattern". That is within the10 days, relatively insignificant fluctuation in the VAS was observed within the entire group. On the other hand, almost every one in the FMS group showed a "fluctuated line pattern" of aggravation, and after that the VAS score rapidly decreased. As a marked decrease in the VAS score occurred when starvation appeared, it suggested the sensation of starvation played an important role in the disappearance of bodily pains with the FMS group.<br>&nbsp;&nbsp;&nbsp;&nbsp;It is therefore concluded that fasting therapy has a beneficial effect on FMS symptoms, as compared to the insignificant effect on RA symptoms, at least in a short period such as 10 days.

著者

小野 純一 樋口 佳則 町田 利生 松田 信二 石毛 聡 永野 修 田島 洋佑

出版者

一般社団法人 日本脳卒中の外科学会

雑誌

脳卒中の外科 (ISSN:09145508)

巻号頁・発行日

vol.43, no.2, pp.118-124, 2015 (Released:2015-05-27)

参考文献数

19

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The natural history of intracranial arterial dissection is not well known. This study was conducted to elucidate the serial changes of radiographic findings and the long-term outcomes in both hemorrhagic and non-hemorrhagic patients who underwent intracranial vertebrobasilar artery dissection.Among 200 patients who underwent intracranial arterial dissection of the vertebrobasilar system, 99 (49.5%) were conservatively managed. These patients were divided into two groups: the hemorrhagic group (H, subarachnoid hemorrhage; n = 24 patients) and non-hemorrhagic group (NH, ischemia or headache; n = 75). Age, site of dissection, initial radiological findings and serial changes, follow-up period, and long-term outcome were analyzed. Outcomes were evaluated using the Glasgow Outcome Scale.Results: The median ages were 54 and 52 years in the H and NH groups, respectively. In both groups, the vertebral artery was most commonly affected, followed by the basilar artery. Regarding radiographic findings, the pearl-and-string sign was the most common initial finding in the H group. Conversely, tapering, narrowing, or occlusion was the most common finding in the NH group. As for serial changes in radiographic findings, no change was most frequent in both groups, followed by improvement. These changes mostly occurred within a few months in the H group but over several years in the NH group. The mean follow-up periods were 7.2 and 5.7 years in the H and NH groups, respectively. Regarding long-term outcomes, in the H group, 15 patients (62.5%) had a good recovery, and 7 (29.2%) died. In the NH group, 58 patients (77.5%) recovered, and 7 (9.3%) died. The cause of poor outcome was initial hemorrhage or subsequent rupture in the H group. Poor outcomes in the NH group were primarily due to systemic problems.These results demonstrate the long-term radiological changes and outcomes associated with the intracranial arterial dissection of the vertebrobasilar system. However, these findings are insufficient to argue the natural history of this disease because patients who received surgical treatment were excluded from this study.

著者

岡本 和彦 梅野 守男 高木 宏治 永野 修司 武田 誉久

出版者

The Japanese Society of Internal Medicine

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.87, no.4, pp.727-729, 1998-04-10

参考文献数

8

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症例は69歳の女性患者. 55歳よりうつ病と診断され,トリプタノール^®(amitryptyline) 20mg/day,アモキサン^®(amoxapine) 25~75mg/dayを内服していた.平成8年8月6日,起床時から意識障害,発熱,筋強直,頻拍,発汗が出現したため,当院に入院となった.入院時の血液検査では白血球増加, CPKの上昇を認め,抗うつ薬の服用歴と臨床症状および検査成績より悪性症候群を疑い,抗うつ薬投与を中止した.しかし,第2病日目より呼吸不全,血小板減少, FDP上昇を呈し, DICの併発を考えた.これらに対して,ソルメドロール^®(methylprednisolone sodium succinate)とFOY^®(gabexate mesilate)の投与を行い経過は良好であった.我々は,長期にわたり少量の抗うつ薬の内服中に,明らかな誘因もなく悪性症候群を発症し呼吸不全, DICを併発し救命しえた稀な症例を経験したので報告した.

著者

原 光生 福本 晴彦 溝下 倫大 永野 修作 関 隆広

出版者

日本液晶学会

雑誌

日本液晶学会討論会講演予稿集

巻号頁・発行日

no.2005, pp.327-328, 2005-09-05

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We prepared silica films hybridized with a chromonic lyotropic liquid crystal, C. I. Direct Blue (B67), by spin-coating. The hybrid films with 2-(2-aminoethoxy) ethanol (AEE) had ordered structures templated by the columnar assemblies of B67. Such structure of the hybrid films was not observed without AEE. Moreover, we studied the hybrid films by dip-coating. As a result, the hybrid films possessed preferred orientation. The columnar assemblies of B67 were aligned to parallel to dipping direction.