著者

永田 勝秀 片山 幸太郎 東條 秀太郎 佐藤 泰生 松沢 耕介

出版者

公益社団法人 日本口腔インプラント学会

雑誌

日本口腔インプラント学会誌 (ISSN:09146695)

巻号頁・発行日

vol.18, no.2, pp.264-272, 2005-06-30 (Released:2014-11-15)

参考文献数

17

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We prepared two types of bone defect fillers (BDFs) which were made from a mixture of α-tricalcium phosphate (α-TCP) with chitosan or alginate in solution. A solidifier was added to the mixtures. These solutions were then kneaded to be solidified. The solid substances, named chitosan-BDF and alginate-BDF, were implanted in femurs of guinea pig to study the effects of the BDFs on the processes of bone formation by EPMA. The alginate-BDF was surrounded with growing bone from all directions at 6 months after the operation and seemed to have an affinity to the tissues. However, no degraded or absorbed form of the BDF was observed. In contrast, most of the chitosan-BDF was replaced by growing bone at 6 months. The adjacent part of the BDF to surrounding cortical bone was especially well-absorbed, probably due to being involved in a reabsorption process after ossification. According to the data, both BDFs were shown to have excellent mechanical properties for filling bone defects. Especially, the chitosan-BDF would be useful as bone defect filler because of its induction of ossification and its smooth absorption.