著者

吉良 満夫 海野 雅史 当麻 博文 百足 勉 河内 卓彌

出版者

公益社団法人 有機合成化学協会

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.62, no.2, pp.162, 2004-02-01 (Released:2009-11-13)

著者

河内 卓彌 百足 勉 Jonathan A. Ellman

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.62, no.2, pp.128-139, 2004-02-01 (Released:2009-11-13)

参考文献数

43

被引用文献数

7 10

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tert-Butanesulfinyl imines are exceedingly versatile intermediates for the asymmetric synthesis of amines. Aldimines 15 and ketimines 16 are prepared in high yields under mild conditions by condensing enantiomerically pure tert-butanesulfinamide 10, either enantiomer of which is readily synthesized in large scale from inexpensive reagents, with a wide range of aldehydes and ketones. The tert-butanesulfinyl group activates the imines for the addition of many different classes of nucleophiles, serves as a powerful chiral directing group, and after nucleophilic addition function as a versatile protecting group of the amines, which is readily cleaved by treatment with acid. A wide range of highly enantioenriched amines, including α-branched amines, α, α-dibranched amines, α- and β-amino acids, 1, 2- and 1, 3-amino alcohols, and α-trifluoromethylamines are efficiently synthesized using this methodology.

著者

岡村 裕 藤井 節郎 河内 卓 川波 寿 桑野 信彦 山村 雄一

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.53, no.4, pp.365-370, 1962 (Released:2008-10-23)

参考文献数

18

被引用文献数

1

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A basic protein fraction having toxohormone activities, isolated from rat Rhodamine sarcoma, was subjected to enzymatic hydrolysis with trypsin, pepsin, and pronase, resulting in the splitting of 12.3%, 19.1%, and 57.4% of peptide bonds of the basic protein respectively.The effect of the hydrolysis on the toxohormone activities of the basic protein was determined by bioassay with rats or mice. Liver catalase depression was markedly diminished by hydrolysis with pronase and pepsin but not by trypsin. Plasma iron decrease was affected by none of these enzymes. Liver tryptophan pyrrolase depression was markedly diminished by hydrolysis with any one of these enzymes.These results suggest that these three different activities of toxohormone are associated with different chemical entities of the basic protein.