著者

油谷 克英

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.49, no.5, pp.226-231, 2009 (Released:2009-09-25)

参考文献数

17

被引用文献数

4 2

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The thermo-stabilization mechanisms of proteins from hyperthermophiles have been thermodynamically elucidated on the basis of protein structures. It focuses on the electrostatic interaction due to ionizable residues unevenly distributed in hyperthermophile proteins and on the denatured structures in equilibrium with the native structures under the physiological conditions. The understanding of the denatured structures under physiological conditions should contribute to studies on folding problems and protein stability.