著者

河野 えみ子 泉 伯枝 安永 浩子 中村 奈緒美 松本 絵麻 奥山 悦子 新崎 孝夫 三箇山 宏樹 岡村 昇

出版者

日本静脈経腸栄養学会

雑誌

静脈経腸栄養 (ISSN:13444980)

巻号頁・発行日

vol.27, no.2, pp.739-745, 2012 (Released:2012-05-10)

参考文献数

6

---

【目的】既報で, 輸液にインスリンを配合した際, pHが高くなるにしたがいブドウ糖やアミノ酸がインスリンの含量低下を起こすことを報告した. 今回, 末梢静脈栄養 (PPN) 輸液や糖加維持液に配合したインスリンの経時的な含量変化を調べ, 含量低下の要因について検討した.【方法】各種のPPN輸液, 糖加維持液にインスリンを配合し, HPLC法にてインスリン含量を経時的に測定した.【結果】PPN輸液中のインスリンの安定性は, 濃度が低いと容器への吸着が, 高いと分解が, それぞれ含量低下の主な要因であった. PPN輸液や糖加維持液でのインスリン含量の低下に製剤間の差は認められなかった. また, 糖加維持液においては輸液のpHが高くなるとインスリンの含量低下はより大きくなった.【結論】PPN輸液や糖加維持液にインスリンを配合した場合, 経時的な含量低下が起きるため, これらに直接配合しない投与方法を選択するべきである.

著者

泉 伯枝 豊田 太一 青木 光夫 大和 孝江

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.41, no.7, pp.455-462, 2015-07-10 (Released:2016-07-10)

参考文献数

2

被引用文献数

1

---

We investigated the relation between the pH value of an infusion solution and the decrease of liquid level in a drip chamber in an infusion set. In the study, an infusion solution (not TPN solution) was admixed with sodium bicarbonate solution (Meylon® Injection) and dripped into an infusion set. It was found that the liquid level in the drip chamber was decreased sharply when the pH value of the infusion solution became smaller than 7. Furthermore, with regard to infusion solutions that showed a large decrease of liquid level, the concentration of CO2 in the drip chamber at the start of drip infusion was approximately 2 v/v% in the conventional procedure where no preventive measures were attempted for such decrease, while its concentration was as high as 15 v/v% when preventive measures were attempted for such decrease. As compared with the conventional procedure, there was no difference in the CO2 concentration at 2 hours of drip infusion. These results indicate that the effect of prevention of decreasing the liquid level in the drip chamber was confirmed by changes in the CO2 concentrations in a drip chamber. The concentration of H2CO3 involved in the decrease of liquid level in the drip chamber was approximately 10% of the total concentration of H2CO3, which was confirmed by measuring H2CO3 concentrations at the end of an infusion set when the infusion solution admixed with Meylon Injection, which showed the largest decrease of liquid level in the drip chamber, was dripped into an infusion set.