著者

深津 俊三

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.40, no.3, pp.188-196, 1982-03-01 (Released:2009-11-13)

参考文献数

27

被引用文献数

3 2

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On the basis of the mechanism of aminoglycoside antibiotic resistance, a number of semisynthetic derivatives of aminoglycoside antibiotics have been synthesized by deoxygenation and acylation. Among them, 3', 4'-dideoxykanamycin B (Dibekacin) and 1-N- [(S) -4-amino-2-hydroxybutyryl] kanamycin A (Amikacin) have been commercialized and now widely used clinically. Dibekacin is demonstrated by our improvement on the industrial synthesis and Amikacin is reviewed from the view point of methodology of the selective acylation.