著者

清水 幸雄 柚原 亜美 矢野 勝子 北川 佳奈子 飯田 純一 五十嵐 信智 伊藤 清美 落合 和 折井 孝男 杉山 清

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.36, no.1, pp.31-36, 2010 (Released:2011-12-24)

参考文献数

17

被引用文献数

6 4

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There is concern about the possibility of degradation of the active substance as a result of pH changes when making suspensions of several drugs together by the simple suspension method.However,this has been investigated by few researchers.In the present study,we focused our attention on aspirin since it is known to be hydrolyzed at high temperatures or with elevation in pH.In this study,a Bufferin® 81 mg Tablet was suspended alone or together with alkaline drugs by the simple suspension method,and its stability evaluated.When in the suspension alone,the Bufferin® 81 mg Tablet was stable for 5 hours and the amount of salicylic acid (hydrolyte of aspirin) produced was negligible.On the other hand,when it was suspended together with alkaline agents (magnesium oxide tablet/powder,or lithium carbonate tablet),the residual content of aspirin decreased to 77-84% in ten minutes.The pH of the suspensions containing both the Bufferin® 81 mg Tablet and alkaline agents ranged from about 9 to 10 showing that alkalinity had been enhanced as compared with the suspension of Bufferin alone whose pH was 4.It has been reported that in low-dose aspirin therapy,platelet aggregation inhibition is unstable if the daily aspirin dosage is reduced to less than 75 mg.However for Bufferin® 81 mg Tablet,the results of the present study suggested that the beneficial effect of low-dose aspirin therapy might not be fully achieved it were suspended together with alkaline agents by the simple suspension method.

著者

井上 卓也 清水 幸雄 鍛治 徹 高崎 眞弓

出版者

一般社団法人 国立医療学会

雑誌

医療 (ISSN:00211699)

巻号頁・発行日

vol.46, no.7, pp.556-558, 1992-07-20 (Released:2011-10-19)

参考文献数

7

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麻痺性貝毒による呼吸筋麻痺の1例を経験した. 59歳の男性. ホタテ稚貝を知人よりもらい受け, 30~40個食べた. 1時間後より口唇, 両手足のしびれ感が現われ, 2時間後には呼吸が停止した. ただちに気管内挿管を行い, 人工呼吸管理を行った. 6時間後より徐々に筋力が回復し, 15時間後には自発呼吸が回復した. 2日後には四肢の麻痺は完全に消失した. 後遺症もなく退院した.