著者

滝田 資也 堀田 知光 山田 英雄 斉藤 宏

出版者

一般社団法人 日本血液学会

雑誌

臨床血液 (ISSN:04851439)

巻号頁・発行日

vol.17, no.5, pp.520-526, 1976

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The distribution patterns of the erythropoietic marrows in 17 patients with polycythemia vera were evaluated with a Ring-type Whole Body Linear Scanning using ⁵⁹Fe. Ferrokinetics indices calculated by Huff's method were as follows: PID T1/2 42±24 min. (Mean±S.D.), RCU 86±17%, PIT 1.00±0.58 mg/kg/day, EIT 0.91±0.61 mg/kg/day. RCU and EIT in polycythemia vera cases with myelofibrotic change were lower than those in polychytemia vera cases without myelofibrotic change. After the injection of ⁵⁹Fe, the longitudihal as well as transverse linear scanning were performed at 6 hours, 24 hours, 5th day and 10th day period. The distribution patterns of ⁵⁹Fe at 24 hours, which reflect the erythropoietic marrow distribution, were devided into 3 patterns, that is, normal, marrow expansion and extramedullary erythropoiesis. Among 20 cases, 5 had normal, 7 had marrow expansion and 13 had extramedullary erythropoiesis. The frequency of extramedullary erythropoiesis was significantly high in patients with splenomegaly. The accumulation of ⁵⁹Fe at the 10th day in the spleen reflecting the hemolysis and the pooling of the red cell was found in 19 among 20 cases with polycythemia vera. The whole body linear scanning is useful for the diagnosis, treatment and studies of pathophysiology of polycythemia vera.