著者

波田野 明日可 住吉谷 淳 鈴木 一真 牛流 章弘 加納 明 加藤 光章 廣畑 賢治 泉 聡志

出版者

一般社団法人 日本機械学会

雑誌

日本機械学会論文集 (ISSN:21879761)

巻号頁・発行日

vol.84, no.863, pp.18-00015, 2018 (Released:2018-07-25)

参考文献数

16

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Transluminal attenuation gradient (TAG) is expected as a noninvasive assessment of the functional significance of a stenosis, and has reported relatively high diagnostic performance. TAG measures the gradient of intraluminal radiological attenuation from the ostium at the first pass of the injected contrast agent; therefore, replacement of fluid by jet flow from a stenosis with gradually increasing contrast agent concentration should be investigated. We performed a phantom experiment and ALE fluid-structure interaction finite element simulation on pulsatile flow through a bifurcated flexible tube system with a stenosis. Experiment and simulation showed good agreement with temporal change of flow rate, pressure, and radius under 1 Hz square pulsatile flow. We varied Young modulus and rate of stenosis with 1 Hz sinusoidal input. Young modulus had little effect on the distribution of total flow, but a changed flow rate waveform and faster maximal velocity in the stenosis was observed with a smaller Young modulus. Then we simulated convection of particle tracers generated at the inlet, imitating a gradual increase in contrast agent with 80% and 95% stenosis. With 80% stenosis, axially symmetric flow resulted in reproductive tracer distributions; however, with 95% stenosis, the direction of jet flow from the stenosis and of subsequent helical flow varied every beat, suggesting this variation might lower sensitivity of TAG.