著者

大西 敦 市田 昭人 牧野 成夫

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.54, no.5, pp.344-353, 1996-05-01 (Released:2010-01-28)

参考文献数

25

被引用文献数

4 4

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The importance of optically active compounds for pharmaceutical usages has increased. High-performance liquid chromatographic (HPLC) resolution on chiral stationary phases (CSPs) is useful for the analysis of the compounds as well the sample preparations to estimate in the developing stages. CSPs consisting of polysaccharide derviatives were developed by adsorbing them on silica gel on the basis of information obtained from cellulose triacetate. The characteristics of cellulosic esters (OA, OB, OJ, OK) and carbamtes (OC, OF, OG, OD), and amylosic carbamtes (AS, AD) in chiral recognition were introduced with many examples. The optimization of sepqrating conditions are discussed in mentioning the differences among the acidic, neutral or basic compounds. Furthermore, we introduced the principle and applications on the Simulated Moving Bed process to produce optically active compounds in the industrial scale as one of the HPLC methods.