著者

四津 まり 村田 道雄 安元 健 直木 秀夫

出版者

天然有機化合物討論会

雑誌

天然有機化合物討論会講演要旨集

巻号頁・発行日

no.29, pp.240-247, 1987-07-25

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The newt Cynops ensicauda collected in Okinawa, Japan, contained tetrodotoxin (TTX)(1) and its new analogs. Two analogs, compound A and B, were isolated by successive treatment of AcOH extracts on columns of charcoal, BioGel P-2, BioRex70, and Hitachigel 3011C gel. From 3.5kg of the newts 120mg of TTX, 18mg of compound A, and 30mg of compound B were obtained. High resolution FAB mass spectra taken on a JEOL JMS-DX-303HF indicated A to have the same molecular formula as TTX(C_<11>H_<17>O_8N_3) and B to be deoxyTTX (C_<11>H_<17>O_7N_3). ^1H NMR spectra of A showed a high field shift of 11-CH_2 suggested the CH_2OH at C-6 to be axial, 6-epiTTX(2) The axial configuration was further confirmed by NOE measurments. Configuration at C-9 was proved to be the same as TTX. Likewise B was assigned to 11-deoxyTTX(3), and its 11-CH_3 was suggested equatorial as same as TTX. Both 2 and I were in a tautomeric equilibrium between hemilactal (2a,3a) and lactone (2b,3b) forms that were confirmed by NOESY measurments which indicated the saturation transfer between two froms.

著者

今田 有美 小野寺 健一 直木 秀夫 安元 健 Imada Yumi Onodera Kenichi Naoki Hideo Yasumoto Takeshi 科学技術振興機構沖縄県地域結集型共同研究事業 Okinawa Prefecture Collaboration of Regional Entities for the Advancement of Technological Excellence Japan Science and Technology Agency

出版者

南方資源利用技術研究会

雑誌

南方資源利用技術研究会誌 = Journal of the society tropical resources technologists (ISSN:09129588)

巻号頁・発行日

vol.22, no.1, pp.13-16, 2006-10-01

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沖縄産の水産資源の機能性素材としての利用を目的に、血圧調節機能と深く関わるACE阻害活性を調べた。オキナワモズク、オキナワモズク盤状体、ヒジキ、アナアオサ、クビレズタ、ヒメシャコガイのペプシン分解物について試験をしたところ、いずれにおいてもACE阻害活性が認められた。今回、最も強い活性を示したのは、沖縄での陸上培養が可能なオキナワモズク盤状体であった。これら沖縄産水産資源を、健康機能を有する素材として広く利用していくことが期待される。