著者

迫 洋介 吉村 英徳 三原 豊 石橋 賢樹 浜本 英利 福井 優

出版者

一般社団法人日本機械学会

雑誌

年次大会講演論文集

巻号頁・発行日

vol.2010, pp.173-174, 2010

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A fabrication method of a painless transdermal micro needle array is proposed to realize its inexpensive and mass production. In order to avoid a risk by breakage of the needle when the needle is penetrated into the epidermis, the array is made with biodegradable polymer, for example, PLA. The proposed method has the following processes, (1) a mold dies having many micro through-holes is heated over the melting point of PLA, (2) the heated mold comes into contact with surface of the PLA plate, (3) the melted PLA is poured into the through-holes, and (4) the formed PLA plate is cooled to less than the melting point and removed from the dies. It is difficult to fabricate the array device because of the ratio of needle height to the diameter is large. So, heating temperature, time of heating the plate, moving stroke of dies and demolding temperature were examined and then fabrication of high precision circular cylindrical shaped needle array became possible.

著者

吉村 英徳 岡本 辰憲 濱本 英利 石橋 賢樹 小林 勝則 三原 豊

出版者

一般社団法人日本機械学会

雑誌

年次大会講演論文集

巻号頁・発行日

vol.2009, pp.109-110, 2009

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A new fabrication method of a painless micro needle array for high reliable vaccine delivery system through a epidermis is proposed. This method has been developed to realize the inexpensive and mass production of the needle array. For safety against the break of the needle, the needle is made with biogradable polymer (PLA). The proposed method has the following processes, (1) Si tool in a shape of micro needle array is heated, (2) tops of the needles over the Si tool are touched onto the surface of the polymer plate to melt the contacting areas, and (3) the Si tool is detached from the plate to form the needles by elongating the melted polymer. In order to make the uniform needles over the plate, temperature, touching time, and withdrawing speed of the Si tool and tolerance of the polymer plate are examined. By the optimized working conditions, keen corn-type needles having the height of about 500μm can be formed enable to penetrate into the epidermis.

著者

迫 洋介 吉村 英徳 三原 豊 石橋 賢樹 浜本 英利 福井 優

出版者

一般社団法人 日本機械学会

雑誌

年次大会講演論文集

巻号頁・発行日

vol.2010, pp.173-174, 2010

---

A fabrication method of a painless transdermal micro needle array is proposed to realize its inexpensive and mass production. In order to avoid a risk by breakage of the needle when the needle is penetrated into the epidermis, the array is made with biodegradable polymer, for example, PLA. The proposed method has the following processes, (1) a mold dies having many micro through-holes is heated over the melting point of PLA, (2) the heated mold comes into contact with surface of the PLA plate, (3) the melted PLA is poured into the through-holes, and (4) the formed PLA plate is cooled to less than the melting point and removed from the dies. It is difficult to fabricate the array device because of the ratio of needle height to the diameter is large. So, heating temperature, time of heating the plate, moving stroke of dies and demolding temperature were examined and then fabrication of high precision circular cylindrical shaped needle array became possible.