著者

石突 吉持 山内 一征 三浦 義孝

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.65, no.2, pp.91-98, 1989-02-20 (Released:2012-09-24)

参考文献数

14

被引用文献数

4 6 2

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日本では, 昆布ヨードの過剰摂取による甲状腺中毒症 (ITT) の報告がない。我々は, 日本人が好んで摂取する昆布の過剰摂取がITTを発症させることを見出した。献立表から算出したヨード量28-140mg/日を毎日摂取し, 1ケ月, 1年を経て甲状腺中毒症を示した42, 59歳の女性例である。両例のT3は高く, T3/T4比, T4/γ-T3比は低く, 無機ヨード値は正常生活者の平均2.05ug/dlの+2SDより高値であった。昆布摂取の禁止後, 1ケ月で中毒症状消失, T4, T3, γ-T3, T4/γ-T3比は正常化した。摂取ヨード源を明らかにするため, 昆布内及び水浸昆布の出汁中ヨード量を測定した。昆布内ヨードの99%が水浸30分, 煮沸15分で水溶液中に出る事を確かめた。以上の結果は, ITTが昆布及び昆布出汁の過剰摂取により発症すること, また, 昆布出汁として1日28mg/日以上のヨード量を毎日摂取すると, 日本人ではITTが引き起こされる可能性があることを示唆している。

著者

石突 吉持

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.79, no.7, pp.922-926, 1990-07-10 (Released:2008-06-12)

参考文献数

5

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ヨード摂取量の多寡は甲状腺疾患の発症,病態に影響を及ぼす.日本人のヨード摂取量は年代,地方により異なり,近年1mg/日以下例が多い. 2mg/日以上のヨードを海藻類から毎日摂り,甲状腺異常を見る例が甲状腺疾患の5%内にある.ヨード誘発は機能低下症,ヨード甲状腺腫が多く,機能亢進症はまれであるが,共にヨード中止後軽快する一過性機能異常である.ヨードは慢性甲状腺炎の進展に関与すると同時に,バセドウ病の機能増悪をも来たし治癒率低下をもたらす.食事指導上,摂取ヨード量は10mg/日内の,間歇摂取が望ましく,ヨード含有薬使用にも注意を与えるべきである.

著者

石突 吉持 広岡 良文 谷川 俊一

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.70, no.10, pp.1093-1100, 1994-12-20 (Released:2012-09-24)

参考文献数

20

被引用文献数

1 4

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In order to evaluate whether or not iodine intake in Japanese is variable among different aged subjects and also whether this variation is concordant with the age distribution in patients with chronic thyroiditis, we tried to examine the urinary iodine excretion of euthyroid people in various decades of age.One hundred and twenty outpatients without thyroid disorders, aged 22 to 77 y. o., were selected at random and were divided into 6 groups according to age. Mean total urinary iodine excretion (UIT) and concentration (UIC) were 336.1μg/day and 31.4μg/dl/cr, respectively, and they were in good correlation (r=+0.82, p<0.001). A straight line on log normal probability was recognized between the ratio of cumulative frequency and values of UIT. UIT and UIC were significantly correlated with serum nonhormonal iodine, respectively (r=+0.21, p<0.01; r=+0.28, p<0.01). These indicators in the 3rd decade were lower than those in the 6th decade (p<0.01, p<0.05). UIT increased with age up to the 6th decade and then decreased gradually to the 8th decade. Therefore, UIT in all the subjects formed a bell-shaped distribution with a significant peak in the 6th decade (H=12.1, p<0.05). Rates of renal iodine clearance (UIC/SNI) in the 6th decade increased significantly more than those in the 4th decade (p<0.01), and the distribution of those rates in the 6 groups were similar to that of UIT. The mean frequency of UIT in less than 200 μg/day of the necessary amounts of iodine intake was 32.5%, but it was 63.6% in the 3rd decade, whereas it was 19% in the 6th decade. The difference between the 3rd and 6th decades was significant (p<0.01).It was indicated that differences in the amounts of iodine intake in Japanese euthyroid people were present and that the distribution was virtually matched to the age distribution of the patients with chronic thyroiditis. The data suggest that the increment of iodine intake in the middle-aged group could affect the pathophysiology of autoimmune thyroid disorders.

著者

石突 吉持 広岡 良文 村田 善晴 富樫 和美

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.67, no.5, pp.622-629, 1991-05-20 (Released:2012-09-24)

参考文献数

12

被引用文献数

1 2

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To elucidate whether soybeans would suppress the thyroid function in healthy adults, we selected 37 subjects who had never had goiters or serum antithyroid antibodies. They were given 30g of soybeans everyday and were divided into 3 groups subject to age and duration of soybean administration.In group 1, 20 subjects were given soybeans for 1 month. Groups 2 and 3 were composed of 7 younger subjects (mean 29 y. o.) and 10 elder subjects (mean 61 y. o.) respectively, and the subjects belonging to these groups received soybeans for 3 months. The Wilcoxon-test and t-test were used in the statistical analyses. In all groups, the various parameters of serum thyroid hormones remained unchanged by taking soybeans, however TSH levels rose significantly although they stayed within normal ranges. The TSH response after TRH stimulation in group 3 revealed a more significant increase than that ingroup 2, although inorganic iodide levels were lowered during the administration of the soybeans. We have not obtained any significant correlation between serum inorganic iodide and TSH.Hypometabolic symptoms (malaise, constipation, sleepiness) and goiters appeared in half the subjects in groups 2 and 3 after taking soybeans for 3 months, but they disappeared 1 month after the cessation of soybean ingestion.These findings suggested that excessive soybean ingestion for a certain duration might suppress thyroid function and cause goiters in healthy people, especially elderly subjects.