本研究においては、主として以下の3つの事業を遂行する。①三世代コホートのアドオンコホートの実施、②オミックス解析と疾患クラスタリング、③クラスタリング結果に基づき、アドオンコホートデータとオミックス解析データのシェアリング及び統合解析によるアトピー性皮膚炎と自閉スペクトラム症のリスク予測式構築及び病態解明。①のアドオンコホートについては、これを実施できる期間が限られている。三世代コホートの児が4歳~5歳となり、センター型調査を受けるのは2021年3月31日ですべての児について完了する。本研究課題の遂行は喫緊の課題であり、この時期に実施しなければ二度とこのような調査は実施できない。
1 0 0 0 OA 生活習慣病における脂質の栄養療法
- 著者
- 菅原 詩緒理
- 出版者
- 日本脂質栄養学会
- 雑誌
- 脂質栄養学 (ISSN:13434594)
- 巻号頁・発行日
- vol.27, no.1, pp.7-13, 2018 (Released:2018-07-16)
Lifestyle diseases such as cancer, heart disease, cerebrovascular disease, are the three leading causes of death among the Japanese, and the prevention of lifestyle diseases is an important issue in Japan. Daily high energy intake and high fat diet are involved in the onset of lifestyle diseases, and nutritional therapy is important for the prevention of lifestyle diseases. Nutritional therapy for lifestyle diseases is based on scientific data which is important to be established. The authors found that lipid nutrition for insulin resistance and non-alcoholic fatty liver disease (NAFLD) from the association of physical measurement, clinical data, nutrient intake and plasma fatty acid composition. As a result, it was suggested that the low levels of n-3 Polyunsaturated Fatty Acids (n-3 PUFA) in plasma phospholipid may be related to insulin resistance, and the decrease in n-3 PUFA intake was also involved in the rise in n-6/n-3 ratio. It was also suggested that increasing NAFLD Score not only reduces energy intake, but also increases fish and n-3 PUFA intakes. The clarification that n-3 PUFA intakes of eicosapentaenoic acid and docosahexaenoic acid is involved in the prevention and improvement of lifestyle related diseases in elucidating the nutritional therapy of lipids in lifestyle related diseases has revealed the importance of lipid nutrition in lifestyle related diseases. It is thought that it contributes to the establishment of nutritional therapy of lipid.