著者

明石 満 赤木 隆美

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.62, no.5, pp.520-528, 2004-05-01 (Released:2009-11-13)

参考文献数

44

被引用文献数

1 1

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Monodisperse polymeric nanospheres, which consist of hydrophobic core and hydrophilic corona on their surfaces, were prepared by the free radical dispersion copolymerization of hydrophobic monomers and hydrophilic macromonomers in a polar solvent. For example, copolymerization of methacrylate-terminated poly (ethylene glycol) (PEG) macromonomers and styrene in ethanol/water mixture gives water dispersible PEG coated nanospheres with a mean diameter around 100-2000 nm. An electron spectroscopy for chemical analysis (ESCA), dynamic light scattering (DLS) and transmission electron microscopy (TEM) observation of ultrathin cross section embedded in a resin supported accumulation of PEG component at the surface of nanospheres. The core-corona type nanospheres can be widely applied to various technological and biomedical applications, because of their possible variety of chemical structure. These nanospheres were utilized as oral drug carriers for peptide drugs physically adsorbed on the nanosphere surfaces, and demonstrated to be useful carrier for incorporating highly water-soluble peptides. Moreover, lectin-immobilized nanospheres could efficiently capture HIV-1 particles and HIV-1-capturing nanospheres may have great potential as a prophylactic vaccine against HIV-1 infection through sexual intercourse.