著者

辛 重基 米沢 養躬

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.41, no.12, pp.1181-1192, 1983-12-01 (Released:2009-11-13)

参考文献数

89

被引用文献数

3 3

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Recently, much attention has been focused on the syntesis of dehydrooligopeptides (DHP), containing one or more α-dehydroamino acid (DHA) residues, and the correlation between the structure and the bioactivity of DHP. The synthetic studies on DHP were reviwed according to the following articles : 1. Introduction.2. Synthesis of dehydrodipeptides.2.1. Synthesis of DHA as carboxy and amine components. 2.2. Stepwise elongation. 2.3. β-Elimination of dipeptide. 2.4. Synthesis of geometric isomer. 2.5. The other elimination methods. 2.6. The other new synthetic methods.3. Synthesis of Dehydrooligopeptides.3. 1. Fragment condensation. 3.2. Synthesis and reactivity of N-carboxy α-dehydroamino acid anhydride (Δ NCA). 3.3 Δ NCA as synthon.3.4. Application of Δ NCA method.4. Conclusion.