著者

通 元夫

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.39, no.7, pp.642-653, 1981-07-01 (Released:2009-11-13)

参考文献数

37

被引用文献数

2

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This review deals with the synthetic studies on trichothecane-type sesquiterpenes and verrucarins. Although more than forty compounds were isolated from natural sources, only a few examples of total synthesis of natural products in this class have been reported. They are trichodermin, trichodermol, 12, 13-epoxytrichothec-9-ene, and trichodiene. The total synthesis of an important sesquiterpene, verrucarol, having tow hydroxyl groups at C-4 and C-15 positions, has not yet succeeded. However, some synthetic studies towards the total synthesis of verrucarol are discussed. In the last part, partial syntheses of macrocyclic derivatives of verrucarol, tetrahydroverrucarin J and 2'-deoxy-3'-hydroxytetrahydroverrucarin A, are described.