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2 0 0 0 Total Synthesis of (±)-, (-)-, and (+)-Oudemansin X

著者
梅澤 勲 野澤 雅子 南雲 紳史 秋田 弘幸
出版者
公益社団法人日本薬学会
雑誌
Chemical & pharmaceutical bulletin (ISSN:00092363)
巻号頁・発行日
vol.43, no.7, pp.1111-1118, 1995-07-15
被引用文献数
1
Three kinds of oudemansin X, (-)-1,(+)-1 and (±)-1,were totally synthesized. The key point in the present chiral synthesis was the enantioselective acetylation of the racemic alcohols, (±)-5 and (±)-8,using lipase in an organic solvent. The synthetic (-)-1 was found to exhibit strong antifungal activity against several molds and yeasts.

1 0 0 0 Total Synthesis of (.+-.)-, (-)-, and (+)-Oudemansin X.

著者
梅澤 勲 野澤 雅子 南雲 紳史 秋田 弘幸
出版者
公益社団法人 日本薬学会
雑誌
CHEMICAL & PHARMACEUTICAL BULLETIN (ISSN:00092363)
巻号頁・発行日
vol.43, no.7, pp.1111-1118, 1995
被引用文献数
5
Three kinds of oudemansin X, (-)-1, (+)-1 and (±)-1, were totally synthesized. The key point in the present chiral synthesis was the enantioselective acetylation of the racemic alcohols, (±)-5 and (±)-8, using lipase in an organic solvent. The synthetic (-)-1 was found to exhibit strong antifungal activity against several molds and yeasts.