著者

阿部 誠也 川名 真理子 舟越 亮寛

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.22, no.4, pp.169-176, 2021-02-28 (Released:2021-03-20)

参考文献数

17

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Objective: Sodium valproate granules (VPA granules) are extremely hygroscopic, deliquesce slowly in the air, and aggregate depending on temperature and humidity conditions. Although pharmacists are required to maintain drug storage conditions until the time of dispensing, they cannot keep track of the actual storage conditions maintained by the patients thereafter. Therefore, we investigated the actual temperature and humidity of the storage conditions maintained by the patients after delivery of the VPA granules.Methods: We conducted a prospective observational study at Kameda Medical Center on pediatric outpatients who were prescribed VPA granules from July 5, 2018 to February 20, 2019. A portable data logger capable of measuring temperature and humidity for 24 h was delivered at the time of dispensation. At the following visit, the data logger was collected, and data about temperature and humidity were obtained. We defined the suitable temperature as 1.0-30.0℃ and suitable humidity as 75.0% or less.Results: In this study, 13 patients were included. In total, 18 data loggers were distributed, and the return rate was 100.0%. The storage temperature was outside the suitable range in 0.8% of the total observation time whereas the humidity exceeded 75.0% in 1.7% of the total observation time.Conclusion: Storage of medications after dispensation was evaluated, and certain temperature and humidity deviations were observed. As storing a drug in an inappropriate environment changes the nature of the drug, affecting its efficacy and safety, it is necessary to educate patients on the proper methods to store oral medications.

著者

堀越 一孝 伊藤 恒 福武 滋 阿部 誠也 角田 賢史 渡邊 宏樹 亀井 徹正

出版者

日本神経治療学会

雑誌

神経治療学 (ISSN:09168443)

巻号頁・発行日

vol.36, no.5, pp.601-605, 2019 (Released:2020-06-02)

参考文献数

7

被引用文献数

1

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Hybrid Assistive Limb医療用下肢タイプ(HAL®)による歩行運動療法を継続した筋萎縮性側索硬化症(amyotrophic lateral sclerosis:ALS)の1例を報告する.症例は61歳女性.4点杖による介助歩行が可能で,座位・立位姿勢にて頸部と体幹の前屈を認めていた.Edaravoneの経静脈的投与と並行して,歩行能力の維持を目的として1クールあたり20分/日×9日を基本とするHAL®による歩行運動療法を開始した.1クール目の終了時には歩行機能が改善し,14~31日のインターバルをおきながら歩行運動療法を継続した.経過を通じて歩行機能は緩徐に低下したが,歩行運動療法の各クール終了時には歩行機能の改善が認められた.また,座位での頸部・体幹の前屈が一過性に改善した.HAL®による歩行運動療法を継続することにより,短期的ではあるが,歩行機能と体幹機能の改善が期待できることが示唆された.