著者

谷野 忠嗣 青木 義広 吉田 達守 鷲見 裕 水田 泰一

出版者

一般社団法人日本PDA製薬学会

雑誌

日本PDA学術誌 GMPとバリデーション (ISSN:13444891)

巻号頁・発行日

vol.2, no.1, pp.19-27, 2000 (Released:2006-08-01)

参考文献数

8

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Fluidized-bed granulation has many operational parameters to be optimized in comparison with other simple wet granulation such as kneading or agitating. In addition, these parameters are not independent of each other: a change in one parameter often influences other parameters. Therefore, difficulties are sometime experienced with scale-up study of fluidized-bed granulation. It is a fact, however, that this granulation method has considerable merits to prepare highly compressible granules which can prevent capping incidents. It is experimentally known that tablets prepared by fluidized-bed granulation have usually higher hardness than those prepared by any other granulation methods. In this study, the authors discussed a scale-up and granule size control strategy on fluidized-bed granulation focusing on the moisture in granulation.

著者

青木 義広 澤本 裕明 根本 孝一 冨士川 恭輔

雑誌

膝 = The knee (ISSN:09111425)

巻号頁・発行日

vol.30, no.1, pp.55-58, 2005-10-20