著者

矢野 耕也 北崎 宏典 高井 忠雄 仲井 由宣

出版者

一般社団法人 品質工学会

雑誌

品質工学 (ISSN:2189633X)

巻号頁・発行日

vol.2, no.5, pp.32-38, 1994-10-01 (Released:2016-03-24)

参考文献数

4

被引用文献数

1

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Generally, a liquid chromatography (LC) is widely used in the field of a chemical and a pharmaceutical analysis. On account of many advances of a modern technique of the instrumental analysis and the appearance of high resolution column, a chemical analysis and a quantitative analysis are done more accurately than before. However, it seems that the determination of the analytical condition is mostly performed empirically. ln development of a new drug research, LC is an indispensable tool for the analysis of the chemical components, and so it is important to get the analytical conditions which is able to performed high degree of the separation. This paper describes that the parameter design was conductedto optimize the analytical condition of a LC. The experiments were conducted on the L₁₈ orthogonal array. Evaluation was done by the S/N ratio and sensitivity in comparison withthe current condition. The optimum condition was determined from the control factor levels which gave the large values of a S/N ratio and sensitivity S. As a result, an improvement was estimated as 3.32db in a S/N ratio. lt seems that this method can be widely applicableto the determination of the analytical conditions of a LC.