著者

馬場 一彦 武市 陽一郎 仲井 由宣

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.38, no.9, pp.2542-2546, 1990-09-25 (Released:2008-03-31)

参考文献数

25

被引用文献数

2 8

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Ground mixtures containing uracill were prepared using various additives such as celluloses, proteins, cyclodextrins, enteric coating agents and inorganic compounds in a planetary ball mill. The amorphous state of uracil was observed in the X-ray diffraction patterns of some of the ground mixtures. The results of infrared spectral analysis indicated deprotonation of uracil after 30 h of (30-h) grinding with sodium polyglutamate. All ground mixtures showed the transient supersaturation of uracil in dissolution studies. The initial amount of uracil dissolved from the 30-h ground mixtures with sodium benzoate derivatives, ethylcellulose, hydroxypropylmethylcellulose acetate succinate and proteins was 2.5 to 9-times that dissolved from intact uracil. The crystallinity and solubility of uracil in the ground mixtures were affected by the mixing ratio, grinding time and moisture content of the additive.

著者

仲井 由宣

出版者

The Society of Powder Technology, Japan

雑誌

粉体工学会誌 (ISSN:03866157)

巻号頁・発行日

vol.25, no.6, pp.388-394, 1988-06-10 (Released:2010-04-30)

参考文献数

21

著者

矢野 耕也 北崎 宏典 仲井 由宣

出版者

一般社団法人 品質工学会

雑誌

品質工学 (ISSN:2189633X)

巻号頁・発行日

vol.3, no.4, pp.41-48, 1995-08-01 (Released:2016-03-24)

参考文献数

6

被引用文献数

1

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Liquid chromatographic/(LC) analysis is an effective instrument for pharmaceutical analysisand pharmaceutical science. Various methods have been utilized in attempts to optimize LC analytical conditions. ln order to obtain a high degree of separation, the optimum conditions were determined by the use of dynamic S/N ratio as an index for the evaluation of the separation process. An L18 orthogonal array was used in this experiment. lt was demonstrated that S/N ratio was an appropriate scale to indicate the separation of some peaks in a LC. Also, the appropriate types of S/N ratio to show the degree of separation in a LC was discussed.

著者

矢野 耕也 北崎 宏典 高井 忠雄 仲井 由宣

出版者

一般社団法人 品質工学会

雑誌

品質工学 (ISSN:2189633X)

巻号頁・発行日

vol.2, no.5, pp.32-38, 1994-10-01 (Released:2016-03-24)

参考文献数

4

被引用文献数

1

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Generally, a liquid chromatography (LC) is widely used in the field of a chemical and a pharmaceutical analysis. On account of many advances of a modern technique of the instrumental analysis and the appearance of high resolution column, a chemical analysis and a quantitative analysis are done more accurately than before. However, it seems that the determination of the analytical condition is mostly performed empirically. ln development of a new drug research, LC is an indispensable tool for the analysis of the chemical components, and so it is important to get the analytical conditions which is able to performed high degree of the separation. This paper describes that the parameter design was conductedto optimize the analytical condition of a LC. The experiments were conducted on the L₁₈ orthogonal array. Evaluation was done by the S/N ratio and sensitivity in comparison withthe current condition. The optimum condition was determined from the control factor levels which gave the large values of a S/N ratio and sensitivity S. As a result, an improvement was estimated as 3.32db in a S/N ratio. lt seems that this method can be widely applicableto the determination of the analytical conditions of a LC.

著者

山口 寿 川真田 正信 仲井 由宣 山本 恵司

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.102, no.5, pp.463-468, 1982-05-25 (Released:2008-05-30)

参考文献数

8

被引用文献数

1 1

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By use of X-ray diffractometry, thermal analysis and infrared spectroscopy, the crystal forms of N-(2, 6-dimethylphenyl)-Δ8-dihydroabietamide were investigated. Two polymorphic forms (form I and II), two solvates (cyclohexane and CCl4), and an amorphous form were identified. Heating of form II induced a solid transformation to form I. The transition of form I and II to the amorphous form was observed by grinding. Each solvate contained 9.0% cyclohexane and 16.0% CCl4 respectively, i.e., drug : solvent=2 : 1. The activation energy of the desolvation was determined from TG curves by using Ozawa's method, and calculated as 72.2 kcal/mol for the cyclohexar solvente, and 35.5 kcal/mol for the CCl4 solvate.

著者

仲井 由宣

出版者

東京大学

巻号頁・発行日

1962

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博士論文

著者

仲井 由宣 山本 恵司 寺田 勝英 内田 武 清水 昶幸 西垣 貞男

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.30, no.7, pp.2629-2632, 1982-07-25 (Released:2008-03-31)

参考文献数

5

被引用文献数

9 14

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The crystal structure of ftorafur, C8H9FN2O3, has been determined by single-crystal X-ray diffraction techniques. The crystal is triclinic, space group P1 ; its unit-cell dimensions are a=8.994 (8), b=16.612 (9), c=5.981 (5) Å, α=86.40 (6), β=94.06 (15), γ=80.29 (8)°, Z=4. The structure was solved by the direct method and the final R value was 0.056.

著者

内田 武 米持 悦生 小口 敏夫 寺田 勝英 山本 恵司 仲井 由宣

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.41, no.9, pp.1632-1635, 1993-09-15 (Released:2008-03-31)

参考文献数

15

被引用文献数

13 20

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Four crystalline forms of tegafur were prepared by recrystallization from different solvents (α-, β-, δ-forms) and by heating (γ-form). They have been characterized using powder X-ray diffraction, thermal analysis, microscopy, density measurements and infrared spectroscopy. From differential scanning calorimetry measurements, it was confirmed that the γ- and δ-forms melted at 175°C and 165°C, whereas the α- and β-forms transformed into the γ-form at about 162°C and 120°C, respectively. The infrared absorption spectral differences observed between the α- and β-forms were discussed in relation to their intermolecular hydrogen bonding systems. It was also found that the difference in crystal forms significantly altered the dissolution rate of tegafur.