5 0 0 0 OA 気管支肺胞洗滌液中の分泌型IgAについて
- 著者
- 高井 晶子 滝 俊彦 竹田 秋郎 辻 宏明 倉田 昌彦 友田 恒典
- 出版者
- The Japanese Respiratory Society
- 雑誌
- 日本胸部疾患学会雑誌 (ISSN:03011542)
- 巻号頁・発行日
- vol.26, no.4, pp.373-377, 1988-04-25 (Released:2010-02-23)
- 参考文献数
- 17
二三の呼吸器疾患にっいて Broncho alveolar lavage fluid (BALF) の液性成分中の分泌型IgA (sIgA) およびその他の免疫グロブリンを測定した. sIgAは気管支炎症例で高く, 対照者とくらべ有意の差 (p<0.02) を認めた. 次いで肺結核症例, 肺癌症例の順であった. 尚喫煙の有無と関係はなかった. IgAは肺結核症例で高く, ついで気管支炎, 肺癌の順であったが, 対照者と有意の差はなかった. IgGは肺結核で高く対照と有意の差 (p<0.01) があった. IgMは量も少なく一定の傾向は認めなかった. またsIgAとIgAは有意の相関関係をみとめたが, sIgAとIgG, sIgAとIgMとの間には相関関係はなかった. sIgAが少ない症例においては弱毒菌の増加が認められ, sIgAが多い症例においてはこれらの微生物の増加は抑制されていた. BALF中のsIgAや免疫グロブリンの測定は病態の解明に有用であることを認めた.
2 0 0 0 OA 喀痰および気管支肺胞洗浄液中の結核菌と感染防御因子
- 著者
- 友田 恒典 高井 晶子
- 出版者
- JAPANESE SOCIETY FOR TUBERCULOSIS
- 雑誌
- 結核 (ISSN:00229776)
- 巻号頁・発行日
- vol.69, no.12, pp.743-749, 1994-12-15 (Released:2011-05-24)
- 参考文献数
- 23
The defence factors against infection in sputum and bronchoalveolar lavage fluid (BALF) of patients with pulmonary tuberculosis were measured. As the defence factors, lactoferrin, lysozyme and secretory IgA (sIgA) in sputum or BALF of patients with bacilli (+) or (-) tuberculosis were measured and compared.Lactoferrin in sputum was significantly higher in patients with sputum smear positive tuberculosis compared with patients with smear and culture negative tuberculosis. SIgA in sputum was significantly higher in smear negative and culture positive cases compared with culture negative cases. As to the lysozyme in sputum, significant difference was not proved between each group. The level of these factors in BALF did not show significant difference between bacilli (+) and (-) cases.Neither significant corelation was observed among the level of three defence factors in sputum or BALF, nor between the number of leucocyte and tubercle bacilli in sputum. In tubercle bacilli positive group, however, significant positive corelation between the number of leucocyte and lactoferrin in sputum was found.In vitro experiments, high concentration of lactoferrin or lysozyme inhibited the growth of standard strain of tubercle bacilli (H37Rv) and BCG.The results suggest that the measurement of lactoferrin, lysozyme and sIgA in sputum or BALF is useful to determine the clinical activity of tuberculosis.