- 著者
-
Yasushi Ueki
Shoichi Kuramitsu
Tatsuya Saigusa
Keisuke Senda
Hitoshi Matsuo
Kazunori Horie
Hiroaki Takashima
Hidenobu Terai
Yuetsu Kikuta
Takayuki Ishihara
Tomohiro Sakamoto
Nobuhiro Suematsu
Yasutsugu Shiono
Taku Asano
Kenichi Tsujita
Katsuhiko Masamura
Tatsuki Doijiri
Yohei Sasaki
Manabu Ogita
Tairo Kurita
Akiko Matsuo
Ken Harada
Kenji Yaginuma
Noriyoshi Kanemura
Shinjo Sonoda
Hiroyoshi Yokoi
Nobuhiro Tanaka
on behalf of the J-CONFIRM Investigators
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- pp.CJ-21-1024, (Released:2022-03-12)
- 参考文献数
- 19
- 被引用文献数
-
1
Background:Little evidence is available regarding the long-term outcome in elderly patients after deferral of revascularization based on fractional flow reserve (FFR).Methods and Results:From the J-CONFIRM registry (long-term outcomes of Japanese patients with deferral of coronary intervention based on fractional flow reserve in multicenter registry), 1,262 patients were divided into 2 groups according to age: elderly and younger patients (aged ≥75 or <75 years, respectively). The primary endpoint was the cumulative 5-year incidence of target vessel failure (TVF), defined as a composite of cardiac death, target vessel-related myocardial infarction (TVMI), and clinically driven target vessel revascularization (CDTVR). Cumulative 5-year incidence of TVF was not significantly different between elderly and younger patients (14.3% vs. 10.8%, P=0.12). Cardiac death occurred more frequently in elderly patients than younger patients (4.4% vs. 0.8%, P<0.001), whereas TVMI and CDTVR did not differ between groups (1.3% vs. 0.9%, P=0.80; 10.7% vs. 10.1%, P=0.80, respectively). FFR values in lesions with diameter stenosis <50% were significantly higher in elderly patients than in younger patients (0.88±0.07 vs. 0.85±0.07, P=0.01), whereas this relationship was not observed in those with diameter stenosis ≥50%.Conclusions:Elderly patients had no excess risk of ischemic events related to the deferred coronary lesions by FFR, although FFR values in mild coronary artery stenosis were modestly different between elderly and younger patients.