- 著者
- Hiroyuki Katsuta Michikazu Nomura Takeo Wakita Hidenori Daido Yumi Kobayashi Atsuko Kawahara Shinichi Banba
- 出版者
- Pesticide Science Society of Japan
- 雑誌
- Journal of Pesticide Science (ISSN:1348589X)
- 巻号頁・発行日
- vol.44, no.2, pp.120-128, 2019-05-20 (Released:2019-05-20)
- 参考文献数
- 17
- 被引用文献数
- 32 49
Broflanilide (1), discovered by Mitsui Chemicals Agro, Inc., has a unique chemical structure characterized as a meta-diamide and exhibits high activity against various pests, including Lepidopteran, Coleopteran, and Thysanopteran pests. Because broflanilide has a novel mode of action, the Insecticide Resistance Action Committee (IRAC) categorized it as a member of a new group: Group 30. The meta-diamide structure was generated via drastic structural modification of a lead compound, flubendiamide (2), and the subsequent structural optimization of meta-diamides on each of its three benzene rings led to the discovery of broflanilide. In the present study, the details of the generation of meta-diamides from the lead compound and the structural optimization of meta-diamides are described.