- 著者
- Atsushi Yamada Yasuo Takeuchi Yuji Nishizaki Hiroyuki Daida
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.51, no.12, pp.1517-1521, 2012 (Released:2012-06-15)
- 参考文献数
- 13
- 被引用文献数
- 8 8
Objective The present study was undertaken to determine the characteristics and outcome of in-hospital cardiac arrests and the effectiveness of BVM ventilation with airway adjuncts including the oropharyngeal airways and nasopharyngeal airways. Methods Information about in-hospital cardiac arrests over a period of 6 years was retrospectively collected, and the effectiveness of BVM ventilation with airway adjuncts was analyzed using a multivariate logistic regression model. Results During the study period, 105 (male, n=70; age, 68.6±14.2 years) cardiac arrests occurred, of which 95.2% developed among inpatients and 21.0% of them were witnessed. The initial rhythm of cardiac arrests was pulseless electrical activity in 63.8% (67/105) and respiratory failure (44.8%) was the most common cause. Overall, a return of spontaneous circulation occurred in 76.2% of in-hospital cardiac arrests, 31.4% survived to discharge, and the neurological outcome was good (cerebral performance category-1) in 66.7% of them. Bag-valve-mask ventilation with airway adjuncts improved the neurological outcome (OR 3.52, 95%CI 1.07, 11.5). Conclusion Bag-valve-mask ventilation with airway adjuncts improved neurological outcomes.
- 著者
- Kazusa Nishiyama Atsushi Yamada Miki Takahashi Tomoharu Takeuchi Ken-ichi Kasai Susumu Kobayashi Hideaki Natsugari Hideyo Takahashi
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.58, no.4, pp.495-500, 2010-04-01 (Released:2010-04-10)
- 参考文献数
- 29
- 被引用文献数
- 15 17
To search for the endogenous glyco-epitope in Caenorhabditis elegans, we synthesized labeled Galβ1-3Fuc and Galβ1-4Fuc and examined their binding affinity for C. elegans galectin LEC-6 using frontal affinity chromatography analysis. We developed a new strategy for synthesizing the labeled saccharides, in which the labeling unit, the 2-aminopyridine moiety, is coupled with a spacer unit derived from D-mannitol. Our results indicate that Galβ1-4Fuc is the endogenous glyco-epitope present in C. elegans N-glycans.