- 著者
- Koji Nishizawa Kosuke Torii Aya Kawasaki Masanori Katada Minoru Ito Kenzo Terashita Sadakazu Aiso Masaaki Matsuoka
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.30, no.9, pp.1758-1762, 2007-09-01 (Released:2007-09-01)
- 参考文献数
- 32
- 被引用文献数
- 17 23
Cordyceps sinensis (CS) has been known as a component of traditional medicines that elicit various biological effects such as anti-fatigue, immunomodulatory, and hypoglycemic actions. Since it has been well-established that fatigue is closely related to depression, we used the tail suspension test (TST) in mice to examine the antidepressant-like effects of hot water extract (HWCS) and supercritical fluid extract (SCCS) of CS. Immobility time in the TST was reduced by administration of SCCS (2.5—10 ml/kg, p.o.) dose-dependently though it was not reduced by treatment with HWCS (500—2000 mg/kg, p.o.). Neither HWCS nor SCCS altered locomotor activity in the open field test, excluding the possibility that the effect of SCCS is due to activation of locomotion. Pretreatment with prazosin (an adrenoreceptor antagonist) or sulpiride (a dopamine D2 receptor antagonist) reduced the effect of SCCS on the immobility time. In contrast, pretreatment with p-chlorophenylalanine (p-CPA, a serotonin synthesis inhibitor) did not alter the anti-immobility effect of SCCS. The last finding is consistent with an additional observation that SCCS had no effect on head twitch response induced by 5-hydroxy-L-tryptophan in mice. Taken altogether, these results suggest that SCCS may elicit an antidepressant-like effect by affecting the adrenergic and dopaminergic systems, but not by affecting the serotonergic system.
- 著者
- Shisei KUBO Aya KAWASAKI Yoshihiko HAYASHI
- 出版者
- The Japanese Society for Dental Materials and Devices
- 雑誌
- Dental Materials Journal (ISSN:02874547)
- 巻号頁・発行日
- vol.30, no.3, pp.374-383, 2011 (Released:2011-06-02)
- 参考文献数
- 50
- 被引用文献数
- 31 46
This study investigated factors associated with the longevity of resin composite restorations, which were placed in 97 patients (mean age of 58 years) by 24 dentists in Nagasaki University Hospital between 1995 and 2005. All patients were under the charge of the principal investigator (SK) and most of them had been regularly checked up for up to 11 years. A total of 503 resin composite restorations (433 by SK and 70 by the other dentists) were analyzed by the Kaplan-Meier and the Cox proportional hazards model. Ten-year survival rates were 84.2% for SK and 71.8% for the others, showing a significant difference. Although the retreatment risk had a great influence on the survival time, gender and age at placement did not have. There were no significant differences in survival between conventional 2-step etch-and-rinse, 2-step self-etch adhesives with and without prior enamel etching. Cavity type had a significant influence, whereas tooth type had no effect.