- 著者
- Koji Nishizawa Kosuke Torii Aya Kawasaki Masanori Katada Minoru Ito Kenzo Terashita Sadakazu Aiso Masaaki Matsuoka
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.30, no.9, pp.1758-1762, 2007-09-01 (Released:2007-09-01)
- 参考文献数
- 32
- 被引用文献数
- 17 23
Cordyceps sinensis (CS) has been known as a component of traditional medicines that elicit various biological effects such as anti-fatigue, immunomodulatory, and hypoglycemic actions. Since it has been well-established that fatigue is closely related to depression, we used the tail suspension test (TST) in mice to examine the antidepressant-like effects of hot water extract (HWCS) and supercritical fluid extract (SCCS) of CS. Immobility time in the TST was reduced by administration of SCCS (2.5—10 ml/kg, p.o.) dose-dependently though it was not reduced by treatment with HWCS (500—2000 mg/kg, p.o.). Neither HWCS nor SCCS altered locomotor activity in the open field test, excluding the possibility that the effect of SCCS is due to activation of locomotion. Pretreatment with prazosin (an adrenoreceptor antagonist) or sulpiride (a dopamine D2 receptor antagonist) reduced the effect of SCCS on the immobility time. In contrast, pretreatment with p-chlorophenylalanine (p-CPA, a serotonin synthesis inhibitor) did not alter the anti-immobility effect of SCCS. The last finding is consistent with an additional observation that SCCS had no effect on head twitch response induced by 5-hydroxy-L-tryptophan in mice. Taken altogether, these results suggest that SCCS may elicit an antidepressant-like effect by affecting the adrenergic and dopaminergic systems, but not by affecting the serotonergic system.
- 著者
- Masaya Inoue Junji Kitao Yoshihiro Miyama Moriyuki Hazeyama Hitoshi Isoda Hideaki Arita Koji Nishizawa Tatsuo Nishimura Masatsugu Nakano
- 出版者
- The Institute of Electrical Engineers of Japan
- 雑誌
- IEEJ Journal of Industry Applications (ISSN:21871094)
- 巻号頁・発行日
- vol.11, no.3, pp.388-395, 2022-05-01 (Released:2022-05-01)
- 参考文献数
- 20
- 被引用文献数
- 6
This paper presents the development of a 48V integrated starter generator (ISG) for mild hybrid vehicles. The motor needs to satisfy power and torque performances requirements under the 48V system voltage as well as the passenger vehicle's specific requirements, such as acoustic noise and layout space. Several processes have been explored to obtain a 48V ISG such as the pole number selection process, the electromagnetic design approach for reducing acoustic noise, and a novel position sensor topology. By using the developed technologies, a 48V ISG motor is designed, built, and tested. Furthermore, the developed motor is demonstrated to achieve 180Nm, 15kW exceeding the 95% motor efficiency with acoustic noise reduction design and thin axial motor length.