著者

CHAEUK IM SAMARENDRA N. MAITI RONALD G. MICETICH MOHSEN DANESHXALAB KEVIN ATCHISON OLUDOTUN A. PHILLIPS CHIEKO KUNUGITA

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.47, no.9, pp.1030-1040, 1994-09-25 (Released:2006-04-19)

参考文献数

15

被引用文献数

31 42

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The synthesis of β-lactamase inhibitory activity of a series of sodium 6-[(1-heteroarylthioethyl-1, 2, 3-triazol-4-yl)methylene]pemcillanate 1, 1-dioxides are described. Their activity was compared with tazobactam and sulbactam. The Z-isomers were more active than the E-isomers. The in vitro activity of the Z-isomers of the phenylthiadiazole derivatives (13a and 15a) was better than sulbactam against the tested β-lactamases and comparable to tazobactam especially against TEM-2 and cephalosporinase. But their synergistic activity with five antibiotics was inferior to tazobactam.